Generic Name and Formulations:
Diphenoxylate HCl 2.5mg, atropine sulfate 0.025mg; tabs.
Adjunct to fluid and electrolyte replacement in diarrhea.
2 tabs or 10mL 4 times daily until diarrhea is controlled. Maintenance: 2 tabs or 10mL daily.
<2yrs: not recommended. 2–12yrs: initially 0.3–0.4mg/kg in 4 divided doses until diarrhea is controlled. Maintenance: 25% initial dose; max 48hrs.
Pseudomembranous enterocolitis. Obstructive jaundice. Diarrhea caused by organisms that penetrate intestinal mucosa. Age <2yrs.
Dehydration. Acute ulcerative colitis; discontinue if toxic megacolon occurs. Hepatic or renal disease. Abnormal liver function tests. Drug abusers. Pregnancy (Cat.C). Nursing mothers.
MAOIs may cause hypertensive crisis. Antimuscarinics may cause paralytic ileus. Potentiates sedation with alcohol, CNS depressants. May delay elimination of other drugs metabolized by CYP450.
Opioid + anticholinergic.
Nausea, vomiting, abdominal discomfort, paralytic ileus, toxic megacolon, dizziness, drowsiness, headache, euphoria, tachycardia, numbness of extremities, pruritus, urticaria, angioneurotic edema, anticholinergic effects; respiratory depression (overdosage), atropinism.
Tabs—100, 500, 1000, 2500; Soln—60mL
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