Generic Name and Formulations:
Labetalol HCl 5mg/mL; soln for IV inj and infusion after dilution; contains parabens.
Various generic manufacturers
Individualize. Maintain supine position; monitor BP. Repeated IV inj: 20mg over 2 minutes, may give additional 40mg or 80mg at 10 minute intervals up to max total dose of 300mg or until desired supine BP. Slow continuous infusion: 2mg/min (see literature).
Bronchial asthma. Overt cardiac failure. 2nd- or 3rd- degree AV block. Cardiogenic shock. Severe bradycardia. Other conditions associated with severe and prolonged hypotension. History of obstructive airway disease (eg, asthma).
Ischemic heart disease or failure. Monitor hepatic function: discontinue at first sign of liver injury. If signs of cardiac failure, treat with digitalis or diuretic, discontinue if failure continues. COPD. Pheochromocytoma. Diabetes. Surgery. Avoid abrupt cessation. Elderly. Pregnancy (Cat.C). Nursing mothers.
Caution with verapamil. Potentiates hypotension with nitroglycerin. May blunt effects of epinephrine, β-agonist bronchodilators. Avoid alkaline drugs (eg, furosemide) administration in same infusion line. Adjust antidiabetic medication. Potentiated by cimetidine and halothane. Tremor with tricyclic antidepressants. May cause false positive urine test for amphetamine.
Noncardioselective beta-blocker/alpha-1 blocker.
Symptomatic postural hypotension, GI upset, dizziness, increased BUN and serum creatinine, paresthesias, sweating, somnolence, flushing, ventricular arrhythmia, vertigo, pruritus.
Formerly known under the brand names Normodyne, Trandate.
Join MIMS Learning now to manage all your CPD and notes in one place!
Already a MIMS Learning member?Sign In Now »
This red flags article explains signs and symptoms of potentially serious pathology in patients presenting...
This article by Dr Tillmann Jacobi covers the possible red flag symptoms to consider when a patient...
Dr Suneeta Kochhar provides an overview of red flag symptoms in patients presenting with headaches...
In this article, Dr David Brass and Dr Neil Rajan discuss the risk factors for BCC, making the diagnosis...
This article by Dr Rajiv Sankaranarayanan covers the diagnosis and management of cardiomyopathy. Key...
Dr Benjamin Simpson provides an in-depth overview of Parkinson’s disease, including information on risk...