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ISOVUE-M 300
Imaging agents
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Drug Name:

ISOVUE-M 300 Rx

Generic Name and Formulations:
Iopamidol 612mg/mL; soln for intrathecal administration; contains sodium 0.043mg, organically bound iodine 300mg per mL.

Company:
Bracco Diagnostics

Therapeutic Use:

Indications for ISOVUE-M 300:

For intrathecal administration in adult neuroradiology inculding myelography (lumbar, thoracic, cervical, total columnar), and for contrast enhancement of computed tomographic (CECT) cisternography and ventriculography.

Adults and Children:

See literature regarding dosing based on procedure.

Contraindications:

Concomitant corticosteroids. Repeat myelography in the event of technical failure. Significant local or systemic infections where bacteremia is likely.

Warnings/Precautions:

Should be administered by professional trained in use of radiopaque agents in appropriate facilities with emergency treatment readily available. Increased intracranial pressure. Intracranial tumor. Abscess. Hematoma. History of convulsive disorder. Severe cardiovascular disease. Chronic alcoholism. Multiple sclerosis. Homozygous sickle cell disease. Multiple myeloma. Pheochromocytoma. Thyroid disorder. Diabetes. Patients with evidence of inadvertant intracranial entry of large or concentrated bolus of contrast medium: increased risk of seizures; consider prophylactic diazepam or barbiturate therapy. Direct intracisternal or ventricular administration for standard radiography: not recommended. Maintain elevation of head during procedure, on the stretcher, or in bed. Avoid excessive and active patient movement or straining. Maintain adequate hydration. Elderly. Pregnancy (Cat.B). Nursing mothers.

Interactions:

Concomitant drugs that lower seizure threshold (eg, phenothiazines, MAOIs, tricyclics, CNS stimulants, analeptics, major tranquilizers, antipsychotics): not recommended; discontinue 48hrs and for at least 24hrs post-procedure. May reduce iodine-binding capacity of thyroid tissue for up to 2 weeks.

See Also:

ISOVUE-M 200

Pharmacological Class:

Contrast media.

Adverse Reactions:

Headache, GI upset, back pain, leg pain, neck pain, hypotension, others.

How Supplied:

ISOVUE-M 200: Single dose vials (10mL, 20mL)—10; ISOVUE-M 300: Single dose vials (15mL)—10

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