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Isosorbide dinitrate
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Drug Name:

Isosorbide dinitrate Rx

Generic Name and Formulations:
Isosorbide dinitrate 2.5mg, 5mg; sublingual tabs.

Various generic manufacturers

Therapeutic Use:

Indications for Isosorbide dinitrate:

Prophylaxis and treatment (in patients that do not respond to sublingual nitroglycerin) of angina.


2.5–5mg sublingually 15 mins before activity; allow a daily dose-free interval of at least 14hrs.


Not established.


Concomitant PDEIs (eg, sildenafil, tadalafil, vardenafil), riociguat.


Recent MI. CHF. Hypotension. Volume depletion. Hypertrophic cardiomyopathy. Tolerance may develop. Elderly. Pregnancy (Cat.C). Nursing mothers.


See Contraindications. Severe hypotension with sildenafil. Hypotension potentiated with alcohol, other vasodilators, calcium channel blockers.

See Also:


Pharmacological Class:


Adverse Reactions:

Headache, orthostatic hypotension, paradoxical bradycardia.


Sublingual tabs formerly known under the brand names Isordil, Sorbitrate.

Generic Availability:

Titradose (YES)

How Supplied:

Sublingual—contact supplier; Titradose—100

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