Generic Name and Formulations:
Isosorbide dinitrate 2.5mg, 5mg; sublingual tabs.
Various generic manufacturers
Prophylaxis and treatment (in patients that do not respond to sublingual nitroglycerin) of angina.
2.5–5mg sublingually 15 mins before activity; allow a daily dose-free interval of at least 14hrs.
Concomitant PDEIs (eg, sildenafil, tadalafil, vardenafil), riociguat.
Recent MI. CHF. Hypotension. Volume depletion. Hypertrophic cardiomyopathy. Tolerance may develop. Elderly. Pregnancy (Cat.C). Nursing mothers.
See Contraindications. Severe hypotension with sildenafil. Hypotension potentiated with alcohol, other vasodilators, calcium channel blockers.
Headache, orthostatic hypotension, paradoxical bradycardia.
Sublingual tabs formerly known under the brand names Isordil, Sorbitrate.
Sublingual—contact supplier; Titradose—100
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