Generic Name and Formulations:
Isosorbide dinitrate 5mg, 40mg; scored oral tabs.
Valeant Pharmaceuticals, Inc
Prophylaxis of angina. Not for acute attacks.
Initially 5–20mg 2–3 times per day. Maintenance: 10–40mg 2–3 times per day; allow a daily dose-free interval of at least 14hrs.
Concomitant PDEIs (eg, sildenafil, tadalafil, vardenafil), riociguat.
Recent MI. CHF. Hypotension. Volume depletion. Hypertrophic cardiomyopathy. Tolerance may develop. Elderly. Pregnancy (Cat.C). Nursing mothers.
See Contraindications. Severe hypotension with sildenafil. Hypotension potentiated with alcohol, other vasodilators, calcium channel blockers.
Headache, orthostatic hypotension, paradoxical bradycardia.
Sublingual tabs formerly known under the brand names Isordil, Sorbitrate.
Sublingual—contact supplier; Titradose—100
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