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INTRALIPID
Parenteral nutrition
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Drug Name:

INTRALIPID Rx

Generic Name and Formulations:
Lipid content 0.2g/mL (refined soybean oil); emulsion for IV infusion; contains aluminum.

Company:
Baxter

Therapeutic Use:

Indications for INTRALIPID:

To provide a source of calories and essential fatty acids for patients requiring parenteral nutrition for extended periods of time (≥5 days). To provide a source of essential fatty acids for prevention of essential fatty acid deficiency (EFAD).

Adult:

Administer by IV infusion via a peripheral or central vein. Initiate rate at 0.5mL/min for the first 15–30mins; if tolerated, may increase to 1mL/min. Do not infuse >500mL on first day; if tolerated, may increase dose the next day; max: 2.5g/kg/day. EFAD: supply 8–10% of caloric input with Intralipid 20%. For complete parenteral nutrition: supplement with amino acids, carbohydrates, electrolytes, multivitamins and trace elements.

Children:

Administer by IV infusion via a peripheral or central vein. Premature infants: initially 0.5g/kg/day; may increase based on ability to eliminate fat; max: 3g/kg/day. Older children: initiate rate at max 0.05mL/min for the first 10–15mins; if tolerated, may increase to 0.5mL/kg/hr. Max dose: 3g/kg/day. EFAD: supply 8–10% of caloric input with Intralipid 20%. For complete parenteral nutrition: supplement with amino acids, carbohydrates, electrolytes, multivitamins and trace elements.

Contraindications:

Disturbances of normal fat metabolism (eg, pathologic hyperlipemia, lipoid nephrosis, acute pancreatitis if accompanied by hyperlipidemia).

Warnings/Precautions:

Risk of deaths in preterm and low birth weight infants: see full labeling. Severe liver damage, pulmonary disease, anemia, blood coagulation disorders, or when there is danger of fat embolism. Monitor serum triglycerides, liver function in long-term use (discontinue if impaired), platelet counts in neonates. Pregnancy (Cat.C). Nursing mothers.

Pharmacological Class:

Fatty acids.

Adverse Reactions:

Sepsis, vein irritation, dyspnea, cyanosis, allergic reactions, hyperlipemia, hypercoagulability, nausea, vomiting, headache, flushing, increase in temperature, sweating, sleepiness, chest and back pain, dizziness, liver dysfunction, blood dyscrasias; aluminum toxicity (esp. preterm infants, renal impairment).

Generic Availability:

NO

How Supplied:

Emulsion (100mL, 250mL, 500mL)—1

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