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INDERAL
Angina
CHF and arrhythmias
Hypertension
Migraine and headache
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Drug Name:

INDERAL Rx

Generic Name and Formulations:
Propranolol HCl 10mg, 20mg, 40mg, 60mg, 80mg; scored tabs.

Company:
Akrimax Pharmaceuticals

Therapeutic Use:

Indications for INDERAL:

Long-term management of angina. Hypertrophic subaortic stenosis.

Adult:

Angina: 80–320mg/day divided into 2, 3, or 4 doses. Stenosis: 20–40mg 3–4 times a day before meals and at bedtime.

Children:

Not recommended.

Contraindications:

Asthma. Sinus bradycardia. 2nd- or 3rd-degree AV block. Overt heart failure. Cardiogenic shock.

Warnings/Precautions:

CHF. Wolff-Parkinson-White syndrome. Renal or hepatic dysfunction. Bronchospastic disease, COPD. Diabetes. Hyperthyroidism. Surgery. SLE. Avoid abrupt cessation. Elderly. Pregnancy (Cat.C). Nursing mothers.

Interactions:

Potentiated by alcohol, CNS depressants, other antihypertensives, antithyroid drugs, haloperidol, chlorpromazine, cimetidine. Bradycardia with catecholamine-depleting drugs. Antagonized by NSAIDs, barbiturates, rifampin, phenytoin. May increase cardiac effects of calcium channel blockers, digitalis, lidocaine. Potentiates theophylline, antipyrine, lidocaine. May block epinephrine. May interfere with glaucoma screening tests.

See Also:

INDERAL LA

Pharmacological Class:

Beta-blocker.

Adverse Reactions:

Heart failure, hypotension, bronchospasm, bradycardia, heart block, fatigue, dizziness, depression, GI upset, skin reactions (eg, rash, Stevens-Johnson syndrome, urticaria), pharyngitis, agranulocytosis.

How Supplied:

Tabs 60mg—100; 10mg, 20mg, 40mg, 80mg—100, 5000; LA—100

Indications for INDERAL:

Atrial and ventricular arrhythmias (see literature). Tachyarrhythmia due to digitalis intoxication. In stabilized patients after MI, to reduce mortality and risk of reinfarction.

Adult:

Arrhythmias: 10–30mg 3–4 times a day before meals and at bedtime. Post-MI: 180–240mg daily in divided doses.

Children:

Not recommended.

Contraindications:

Asthma. Sinus bradycardia. 2nd- or 3rd-degree AV block. Overt heart failure. Cardiogenic shock.

Warnings/Precautions:

CHF. Wolff-Parkinson-White syndrome. Renal or hepatic dysfunction. Bronchospastic disease, COPD. Diabetes. Hyperthyroidism. Surgery. SLE. Avoid abrupt cessation. Elderly. Pregnancy (Cat.C). Nursing mothers.

Interactions:

Potentiated by alcohol, CNS depressants, other antihypertensives, antithyroid drugs, haloperidol, chlorpromazine, cimetidine. Bradycardia with catecholamine-depleting drugs. Antagonized by NSAIDs, barbiturates, rifampin, phenytoin. May increase cardiac effects of calcium channel blockers, digitalis, lidocaine. Potentiates theophylline, antipyrine, lidocaine. May block epinephrine. May interfere with glaucoma screening tests.

Pharmacological Class:

Beta-blocker.

Adverse Reactions:

Heart failure, hypotension, bronchospasm, bradycardia, heart block, fatigue, dizziness, depression, GI upset, skin reactions (eg, rash, Stevens-Johnson syndrome, urticaria), pharyngitis, agranulocytosis.

How Supplied:

Tabs 60mg—100; 10mg, 20mg, 40mg, 80mg—100, 5000

Indications for INDERAL:

Hypertension. Adjunct in pheochromocytoma.

Adult:

Initially 40mg twice a day. Usual maintenance: 120–240mg daily; max 640mg daily. Pheochromocytoma: 60mg daily in divided doses for 3 days pre-op or 30mg daily in inoperable cases.

Children:

Initially 1mg/kg daily. Usual range: 2–4mg/kg per day in 2 divided doses; max 16mg/kg per day.

Contraindications:

Asthma. Sinus bradycardia. 2nd- or 3rd-degree AV block. Overt heart failure. Cardiogenic shock.

Warnings/Precautions:

CHF. Wolff-Parkinson-White syndrome. Renal or hepatic dysfunction. Bronchospastic disease, COPD. Diabetes. Hyperthyroidism. Surgery. SLE. Avoid abrupt cessation. Elderly. Pregnancy (Cat.C). Nursing mothers.

Interactions:

Potentiated by alcohol, CNS depressants, other antihypertensives, antithyroid drugs, haloperidol, chlorpromazine, cimetidine. Bradycardia with catecholamine-depleting drugs. Antagonized by NSAIDs, barbiturates, rifampin, phenytoin. May increase cardiac effects of calcium channel blockers, digitalis, lidocaine. Potentiates theophylline, antipyrine, lidocaine. May block epinephrine. May interfere with glaucoma screening tests.

See Also:

INDERAL LA

Pharmacological Class:

Beta-blocker.

Adverse Reactions:

Heart failure, hypotension, bronchospasm, bradycardia, heart block, fatigue, dizziness, depression, GI upset, skin reactions (eg, rash, Stevens-Johnson syndrome, urticaria), pharyngitis, agranulocytosis.

How Supplied:

Tabs 60mg—100; 10mg, 20mg, 40mg, 80mg—100, 5000; LA—100

Indications for INDERAL:

Migraine prophylaxis.

Adult:

Initially 80mg daily in divided doses. Usual range: 160–240mg daily. Discontinue if poor result after 4–6 weeks.

Children:

Not recommended.

Contraindications:

Asthma. Sinus bradycardia. 2nd- or 3rd-degree AV block. Overt heart failure. Cardiogenic shock.

Warnings/Precautions:

CHF. Wolff-Parkinson-White syndrome. Renal or hepatic dysfunction. Bronchospastic disease, COPD. Diabetes. Hyperthyroidism. Surgery. SLE. Avoid abrupt cessation. Elderly. Pregnancy (Cat.C). Nursing mothers.

Interactions:

Potentiated by alcohol, CNS depressants, other antihypertensives, antithyroid drugs, haloperidol, chlorpromazine, cimetidine. Bradycardia with catecholamine-depleting drugs. Antagonized by NSAIDs, barbiturates, rifampin, phenytoin. May increase cardiac effects of calcium channel blockers, digitalis, lidocaine. Potentiates theophylline, antipyrine, lidocaine. May block epinephrine. May interfere with glaucoma screening tests.

See Also:

INDERAL LA

Pharmacological Class:

Beta-blocker.

Adverse Reactions:

Heart failure, hypotension, bronchospasm, bradycardia, heart block, fatigue, dizziness, depression, GI upset, skin reactions (eg, rash, Stevens-Johnson syndrome, urticaria), pharyngitis, agranulocytosis.

How Supplied:

Tabs 60mg—100; 10mg, 20mg, 40mg, 80mg—100, 5000; LA—100

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