This site is intended for healthcare professionals

ADD THIS DRUG TO MY LIST

Select the drug indication to add to your list

IMPAVIDO
Protozoal infections
Compare To Related Drugs
View/Edit/Compare Drugs In My List

Only 4 drugs may be compared at once

Drug Name:

IMPAVIDO Rx

Generic Name and Formulations:
Miltefosine 50mg; hard gel caps.

Company:
Profounda, Inc.

Therapeutic Use:

Indications for IMPAVIDO:

Treatment of visceral, cutaneous, and mucosal leishmaniasis due to susceptible Leishmania species.

Limitations Of use:

Not evaluated in treatment of other Leishmania species. Leishmania species studied in clinical trials were based on epidemiologic data; geographic variation in clinical response of the same Leishmania species may exist.

Adult:

Swallow whole. Take with food. Treat for 28 consecutive days. ≥12yrs (30–44kg): 50mg twice daily (breakfast and dinner); (≥45kg): 50mg three times daily (breakfast, lunch, and dinner).

Children:

Not established.

Contraindications:

Pregnancy (Cat.D). Sjӧgren-Larsson-Syndrome.

Warnings/Precautions:

Embryo-fetal toxicity; obtain a serum or urine pregnancy test in females of reproductive potential prior to prescribing; use effective contraception during therapy and for 5 months after completion; use additional non-hormonal or alternative methods of contraception if vomiting/diarrhea occur during therapy. Possibly reproductive effects (eg, impaired fertility). Monitor renal function weekly during therapy and for 4 weeks after completion. Monitor platelets (for visceral leishmaniasis), ALT, AST, and bilirubin during therapy. Maintain adequate hydration. Discontinue if exfoliative or bullous rash develops. Nursing mothers: not recommended (during and for 5 months after therapy).

Pharmacological Class:

Antileishmanial agent.

Adverse Reactions:

Nausea, vomiting, diarrhea, decreased appetite, headache, motion sickness, dizziness, abdominal pain, pruritus, somnolence, elevated transaminases, elevated creatinine; thrombocytopenia, others.

Generic Availability:

NO

How Supplied:

Caps—28 (2 × 14 blister cards)

Join MIMS Learning now to manage all your CPD and notes in one place!

By registering you agree with our Terms and Conditions and Privacy Policy.


Already a MIMS Learning member?

Sign In Now »
Red flag CPD modules
0.50 Credits
Red flags

Fever in adults - red flag symptomsExternal web site

Fever in adults can have potentially serious causes, ranging from sepsis to malignancy. Dr Pipin Singh...

0.50 Credits
Red flags

Bone pain - red flag symptomsExternal web site

In this article Dr Pipin Singh advises on how to identify red flags in patients presenting with bone...

0.50 Credits
Red flags

Pregnancy - red flag symptomsExternal web site

Dr Matthew West covers the red flags to look out for in pregnancy, including back pain, bleeding, headaches...

Font Awesome Icons
View more
Clinical review CPD modules
1.50 Credits
Clinical Review

Bronchiectasis: clinical reviewExternal web site

This article, updated in 2016 by Dr Anthony De Soyza, advises on causes, investigations and managing...

1.50 Credits
Clinical Review

Brugada syndrome: clinical reviewExternal web site

Dr Keith Barnard discusses the aetiology and symptoms of Brugada syndrome. Key learning points for GPs...

1.50 Credits
Clinical Review

Measles: clinical reviewExternal web site

Dr Kirsty Le Doare and Dr Nuria Martinez-Alier describe the signs and symptoms of measles and outline...

Font Awesome Icons
View more

is free, fast, and customized just for you!

Already a member?

Sign In Now »