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IFEX
Prostate and other male cancers
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Drug Name:

IFEX Rx

Generic Name and Formulations:
Ifosfamide 1g, 3g; per vial; pwd for IV infusion after reconstitution.

Company:
Baxter

Therapeutic Use:

Indications for IFEX:

Third-line adjunctive treatment of germ cell testicular cancer.

Adult:

Give by slow IV infusion over at least 30 mins. 1.2g/m2 per day for 5 consecutive days; repeat every 3 weeks or after hematological recovery (platelets ≥100000/µL, WBC ≥4000/µL).

Children:

Not recommended.

Contraindications:

Severe bone marrow depression.

Warnings/Precautions:

Discontinue if neurologic effects (eg, somnolence, confusion, hallucinations) occur. Do urinalysis before each dose, postpone dose if hematuria occurs. Give mesna and at least 2L fluids daily. Do hematologic profile before each dose; discontinue if WBCs <2000/µL or platelets <50000/µL. May interfere with wound healing. Impaired hepatic, renal, or hematopoetic function. Prior radiation therapy or other cytotoxic agents. Ensure adequate hydration. Pregnancy (Cat.D). Nursing mothers: not recommended.

Interactions:

Increased risk of myelosuppression with other chemotherapy agents.

Pharmacological Class:

Alkylating agent.

Adverse Reactions:

Alopecia, GI upset, hematuria, CNS toxicity, infection, renal or liver dysfunction, phlebitis, fever, urotoxicity (eg, hemorrhagic cystitis), leukopenia, thrombocytopenia.

How Supplied:

Single-dose vials—1

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