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IDAMYCIN PFS
Leukemias, lymphomas, and other hematologic cancers
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Drug Name:

IDAMYCIN PFS Rx

Generic Name and Formulations:
Idarubicin 1mg/mL; soln for IV infusion; preservative-free.

Company:
Pfizer Inc.

Therapeutic Use:

Indications for IDAMYCIN PFS:

Acute myeloid leukemia.

Adult:

Give by slow IV infusion (over 10–15 mins). 12mg/m2 daily for 3 days (in combination with cytarabine). May give 2nd course if needed; if toxicity develops after 1st course, delay until resolved; reduce dose by 25%. Hepatic and renal impairment: consider reduce dose.

Children:

Not established.

Warnings/Precautions:

Pre-existing bone marrow suppression. Cardiovascular disease. Thoracic irradiation. Previous anthracycline therapy at high cumulative doses. Renal or hepatic impairment. Monitor CBCs, cardiac, renal and hepatic function prior to and during treatment. Avoid extravasation. Elderly. Pregnancy (Cat.D); avoid use. Nursing mothers: not recommended.

Interactions:

Concomitant drugs that suppress cardiac contractility or cardiotoxic drugs (eg, trastuzumab, cyclophosphamide, paclitaxel): not recommended; avoid use for 5 half-lives after discontinuing cardiotoxic drug.

See Also:

IDAMYCIN

Pharmacological Class:

Anthracycline.

Adverse Reactions:

Myelosuppression, GI upset, mucositis, abdominal pain, alopecia, rash, inj site reactions, hepatotoxicity, renal toxicity, cardiotoxicity (eg, CHF, arrhythmias, chest pain, MI, asymptomatic declines in LVEF), hyperuricemia.

How Supplied:

Single-dose vials—1; PFS: Single-dose vials (5mL, 10mL, 20mL)—1

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