This site is intended for healthcare professionals


Select the drug indication to add to your list

Miscellaneous Ob/Gyn conditions
Compare To Related Drugs
View/Edit/Compare Drugs In My List

Only 4 drugs may be compared at once

Drug Name:


Generic Name and Formulations:
Carboprost (as tromethamine salt) 250mcg/mL; soln for IM inj; contains benzyl alcohol.

Pfizer Inc.

Therapeutic Use:

Indications for HEMABATE:

For aborting pregnancy between the 13th and 20th weeks of gestation in the following conditions related to second trimester abortion: 1) failure of expulsion of the fetus during the course of treatment by another method; 2) premature rupture of membranes in intrauterine methods with loss of drug and insufficient or absent uterine activity; 3) requirement of a repeat intrauterine instillation of drug for expulsion of the fetus; 4) inadvertent or spontaneous rupture of membranes in the presence of a previable fetus and absence of adequate activity for expulsion. For the treatment of postpartum hemorrhage due to uterine atony which has not responded to conventional methods of management.


Give by deep IM inj. Abortion: 250mcg; subsequent doses of 250mcg should be given at 1.5–3.5 hour intervals depending on uterine response. Optional test dose (100mcg) may be given initially. Dose may be increased to 500mcg if uterine contractility is judged to be inadequate after several doses of 250mcg. Max total dose: 12mg; continuous administration for >2 days not recommended. Refractory postpartum uterine bleeding: initially 250mcg once, may give additional doses at intervals of 15–90 mins if necessary. Max total dose: 2mg (8 doses).


Not applicable.


Acute pelvic inflammatory disease. Active cardiac, pulmonary, renal or hepatic disease.


Should only be used by trained personnel in a hospital which can provide immediate intensive care and acute surgical facilities. Not indicated if fetus in utero has reached stage of viability. History of asthma, hypo- or hypertension, cardiovascular, renal, or hepatic disease, anemia, jaundice, diabetes, epilepsy. Compromised (scarred) uteri. Chorioamnionitis. Pregnancy (Cat.C).


Concomitant other oxytocic agents: not recommended.

Pharmacological Class:


Adverse Reactions:

Vomiting, diarrhea, nausea, flushing, chills, headache, pain, breast tenderness; transient pyrexia (see full labeling re: PGEs induced pyrexia vs. endometritis pyrexia), others.

How Supplied:

Ampules (1mL)—1, 10

Join MIMS Learning now to manage all your CPD and notes in one place!

By registering you agree with our Terms and Conditions and Privacy Policy.

Already a MIMS Learning member?

Sign In Now »
Red flag CPD modules
0.50 Credits
Red flags

Groin swelling - red flag symptomsExternal web site

This red flags article explains signs and symptoms of potentially serious pathology in patients presenting...

0.50 Credits
Red flags

Erectile dysfunction - red flag symptomsExternal web site

This article by Dr Tillmann Jacobi covers the possible red flag symptoms to consider when a patient...

0.50 Credits
Red flags

Headache - red flag symptomsExternal web site

Dr Suneeta Kochhar provides an overview of red flag symptoms in patients presenting with headaches...

Font Awesome Icons
View more
Clinical review CPD modules
1.50 Credits
Clinical Review

Basal cell carcinoma: clinical reviewExternal web site

In this article, Dr David Brass and Dr Neil Rajan discuss the risk factors for BCC, making the diagnosis...

1.50 Credits
Clinical Review

Cardiomyopathy: clinical reviewExternal web site

This article by Dr Rajiv Sankaranarayanan covers the diagnosis and management of cardiomyopathy. Key...

1.50 Credits
Clinical Review

Parkinson's disease: clinical reviewExternal web site

Dr Benjamin Simpson provides an in-depth overview of Parkinson’s disease, including information on risk...

Font Awesome Icons
View more

is free, fast, and customized just for you!

Already a member?

Sign In Now »