Generic Name and Formulations:
Granisetron HCl 1mg.
Various generic manufacturers
Prevention of nausea and vomiting associated with chemotherapy (including high-dose cisplatin), and with radiation (including total body irradiation and fractionated abdominal radiation).
Chemotherapy: give only on the days chemotherapy is given. 2mg up to 1 hour before chemotherapy; or, 1mg up to 1 hour before chemotherapy, then 1mg 12 hours after initial dose. Radiation: 2mg within 1 hour of radiation.
Use IV form.
Abdominal surgery. May mask progressive ileus and/or gastric distention. Pre-existing arrhythmias or cardiac conduction disorders. Cardiac disease, concomitant cardio-toxic chemotherapy or electrolyte abnormalities: increased risk of QT prolongation. Pregnancy (Cat.B). Nursing mothers.
Caution with drugs that affect CYP450 or prolong the QT interval.
Selective 5-HT3 receptor antagonist.
Headache, asthenia, diarrhea, constipation; QT prolongation.
Formerly known under the brand name Kytril.
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