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Granisetron HCl Tablets
Nausea
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Drug Name:

Granisetron HCl Tablets Rx

Generic Name and Formulations:
Granisetron HCl 1mg.

Company:
Various generic manufacturers

Therapeutic Use:

Indications for Granisetron HCl Tablets:

Prevention of nausea and vomiting associated with chemotherapy (including high-dose cisplatin), and with radiation (including total body irradiation and fractionated abdominal radiation).

Adult:

Chemotherapy: give only on the days chemotherapy is given. 2mg up to 1 hour before chemotherapy; or, 1mg up to 1 hour before chemotherapy, then 1mg 12 hours after initial dose. Radiation: 2mg within 1 hour of radiation.

Children:

Use IV form.

Warnings/Precautions:

Abdominal surgery. May mask progressive ileus and/or gastric distention. Pre-existing arrhythmias or cardiac conduction disorders. Cardiac disease, concomitant cardio-toxic chemotherapy or electrolyte abnormalities: increased risk of QT prolongation. Pregnancy (Cat.B). Nursing mothers.

Interactions:

Caution with drugs that affect CYP450 or prolong the QT interval.

See Also:

Granisetron HCl Injection

Pharmacological Class:

Selective 5-HT3 receptor antagonist.

Adverse Reactions:

Headache, asthenia, diarrhea, constipation; QT prolongation.

Note:

Formerly known under the brand name Kytril.

How Supplied:

Contact supplier.

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