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GLIADEL
CNS cancers
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Drug Name:

GLIADEL Rx

Generic Name and Formulations:
Carmustine 7.7mg, polifeprosan 20; per wafer.

Company:
Arbor Pharmaceuticals, LLC

Therapeutic Use:

Indications for GLIADEL:

Newly-diagnosed high-grade malignant glioma as an adjunct to surgery and radiation. Recurrent glioblastoma multiforme as an adjunct to surgery.

Adult:

See literature. Place 8 wafers (61.6mg) in the resection cavity if the size and shape of it allows; max 8 wafers per surgical procedure.

Children:

Not recommended.

Warnings/Precautions:

Avoid communication between surgical resection cavity and ventricular system to prevent wafer from migrating and causing obstructive hydrocephalus. If communication larger than diameter of wafer exists, it should be closed prior to wafer implantation. Pregnancy (Cat.D). Nursing mothers: not recommended.

Pharmacological Class:

Nitrosurea.

Adverse Reactions:

Abdominal pain, back pain, chest pain, intracranial hypertension, abnormal healing, brain edema, meningitis or abscess; intracerebral mass effect.

How Supplied:

Single-dose treatment box (8 wafers)—1

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