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Arthritis/rheumatic disorders
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Drug Name:


Generic Name and Formulations:
Sodium hyaluronate 0.84%; per 2mL; soln for intra-articular inj.


Therapeutic Use:

Indications for GELSYN-3:

Treatment of pain in osteoarthritis of the knee in patients who have failed to respond adequately to conservative nonpharmacologic therapy and simple analgesics (eg, acetaminophen).


Remove synovial fluid or effusion before inj. Give as a single intra-articular inj. >21yrs: 2mL in one knee only once weekly for 3 weeks.


≤21yrs: not established.


Knee joint infections. Skin diseases or infections in area of the inj site.


Do not inject by intravascular route. Severe intra-articular effusion. Lymphatic or venous stasis in leg. Advise patients to avoid strenuous or prolonged weight-bearing activities for approx. 48hrs following inj. Pregnancy, nursing mothers: not established.


Avoid use of disinfectants containing quaternary ammonium salts; hyaluronan can precipitate in their presence. Concomitant other intra-articular inj: not studied.

Pharmacological Class:


Adverse Reactions:

Inj site pain, arthralgia, joint effusion/warmth/stiffness/swelling, arthritis, gait disturbance, arthropathy.

Generic Availability:


How Supplied:

Single-use pre-filled syringe—1 (w. needle)

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