Generic Name and Formulations:
Nitrofurantoin 25mg/5mL; susp.
Take with food. 50–100mg 4 times daily. Suppressive therapy: 50–100mg once daily at bedtime may suffice.
Take with food. <1month: contraindicated. ≥1month: 5–7mg/kg per day in 4 divided doses. Suppressive therapy: 1mg/kg per day in 1–2 divided doses may suffice.
Renal impairment (CrCl <60mL/min or significantly elevated serum creatinine), anuria, oliguria. Neonates. Labor & delivery. Pregnancy at term. History of cholestatic jaundice or hepatic dysfunction.
Not for treating pyelonephritis or perinephric abscesses. Discontinue if pulmonary or hepatic disorders, hemolysis, or peripheral neuropathy occurs. Renal insufficiency. G6PD or Vit. B deficiency. Anemia. Diabetes. Electrolyte imbalance. Debilitated. Monitor renal and pulmonary function in long-term use. Pregnancy (Cat.B). Nursing mothers: not recommended.
Avoid magnesium trisilicate. Antagonized by, and increased toxicity with uricosurics (eg, probenecid). May cause false (+) glucose test with Benedict's or Fehling's solution.
Nausea, emesis, anorexia, dizziness, headache, pulmonary or hematological disorders (esp. in long-term use), peripheral neuropathy, allergic reactions, C. difficile-associated diarrhea; rare: hepatic dysfunction, exfoliative dermatitis, Stevens-Johnson syndrome, optic neuritis, methemoglobinemia.
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