This site is intended for healthcare professionals


Select the drug indication to add to your list

Pulmonary hypertension
Compare To Related Drugs
View/Edit/Compare Drugs In My List

Only 4 drugs may be compared at once

Drug Name:


Generic Name and Formulations:
Epoprostenol (as sodium) 0.5mg, 1.5mg; per vial; pwd for IV infusion after reconstitution.


Therapeutic Use:

Indications for FLOLAN:

Primary pulmonary hypertension. Pulmonary hypertension due to scleroderma disease in NYHA Class III and Class IV patients who do not respond adequately to conventional therapy.


Give by continuous chronic IV infusion through a central venous catheter. Initially 2 nanograms/kg per min; increase in increments of 2 nanograms/kg per min at ≥15 minute intervals until response achieved or tolerance develops. Dose decreases should be made gradually in 2 nanograms/kg/min decrements at ≥15 minute intervals until dose-limiting effects resolve.


Not recommended.


Chronic use with CHF due to severe left ventricular systolic dysfunction. Pulmonary edema.


Avoid abrupt withdrawal or large dose reductions (may cause rebound pulmonary hypertension). Bleeding disorders. Start anticoagulant therapy, unless contraindicated. Monitor BP and heart rate for several hours after dose changes. Pregnancy (Cat.B). Labor & delivery. Nursing mothers.


Potentiated hypotensive effects with diuretics, antihypertensive agents, other vasodilators. Potentiates anticoagulants, antiplatelet agents. May potentiate digoxin (monitor).

Pharmacological Class:


Adverse Reactions:

Headache, jaw pain, flushing, GI upset, flu-like symptoms, anxiety, dizziness, tachycardia, myalgia.

How Supplied:

Vials—1 (w. diluent)

Join MIMS Learning now to manage all your CPD and notes in one place!

By registering you agree with our Terms and Conditions and Privacy Policy.

Already a MIMS Learning member?

Sign In Now »
Red flag CPD modules
0.50 Credits
Red flags

Groin swelling - red flag symptomsExternal web site

This red flags article explains signs and symptoms of potentially serious pathology in patients presenting...

0.50 Credits
Red flags

Erectile dysfunction - red flag symptomsExternal web site

This article by Dr Tillmann Jacobi covers the possible red flag symptoms to consider when a patient...

0.50 Credits
Red flags

Headache - red flag symptomsExternal web site

Dr Suneeta Kochhar provides an overview of red flag symptoms in patients presenting with headaches...

Font Awesome Icons
View more
Clinical review CPD modules
1.50 Credits
Clinical Review

Basal cell carcinoma: clinical reviewExternal web site

In this article, Dr David Brass and Dr Neil Rajan discuss the risk factors for BCC, making the diagnosis...

1.50 Credits
Clinical Review

Cardiomyopathy: clinical reviewExternal web site

This article by Dr Rajiv Sankaranarayanan covers the diagnosis and management of cardiomyopathy. Key...

1.50 Credits
Clinical Review

Parkinson's disease: clinical reviewExternal web site

Dr Benjamin Simpson provides an in-depth overview of Parkinson’s disease, including information on risk...

Font Awesome Icons
View more

is free, fast, and customized just for you!

Already a member?

Sign In Now »