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FLAGYL 375
Bacterial infections
Protozoal infections
Vaginal infections
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Drug Name:

FLAGYL 375 Rx

Generic Name and Formulations:
Metronidazole 375mg; caps.

Company:
Pfizer Inc.

Therapeutic Use:

Indications for FLAGYL 375:

Susceptible anaerobic infections, including intraabdominal, skin and skin structures, gynecologic, bacterial septicemia, bone and joint, CNS, lower respiratory tract, endocarditis.

Adult:

Parenteral form usually used first. 7.5mg/kg every 6 hours for 7–10 days; max 4g/day.

Children:

Not recommended.

Contraindications:

Pregnancy (1st trimester for trichomoniasis).

Warnings/Precautions:

CNS disease. Discontinue if neurological symptoms occur. Severe hepatic disease: reduce dose. Candidiasis. History of blood dyscrasias. Monitor leukocytes before and after therapy. Elderly: monitor serum levels. Pregnancy (Cat.B). Nursing mothers: not recommended.

Interactions:

Avoid alcohol during and for 3 days after use. Do not give within 2 weeks of disulfiram (possible psychotic reactions). May potentiate oral anticoagulants, phenytoin, lithium. Antagonized by phenobarbital, phenytoin, other hepatic enzyme inducers. May impair phenytoin clearance. Potentiated by cimetidine, other hepatic enzyme inhibitors. Interferes with serum chemistry tests.

See Also:

FLAGYL

FLAGYL I.V. INJECTION

Pharmacological Class:

Nitroimidazole.

Adverse Reactions:

Seizures, peripheral neuropathy, GI upset, anorexia, constipation, headache, metallic taste, ECT changes, dysuria.

How Supplied:

Tabs—50, 100; Caps 375mg—50; IV—24

Indications for FLAGYL 375:

Amebic dysentery. Amebic liver abscess.

Adult:

Dysentery: 750mg. Abscess: 500–750mg. Both: 3 times daily for 5–10 days.

Children:

35–50mg/kg/day in 3 divided doses for 10 days.

Contraindications:

Pregnancy (1st trimester for trichomoniasis).

Warnings/Precautions:

CNS disease. Discontinue if neurologic symptoms occur. Severe hepatic disease: reduce dose. History of blood dyscrasias. Candidiasis. Monitor leukocytes before and after therapy. Elderly: monitor serum levels. Pregnancy (Cat.B). Nursing mothers: not recommended.

Interactions:

Avoid alcohol during and for 3 days after use. Do not give within 2 weeks of disulfiram (possible psychotic reactions). May potentiate oral anticoagulants, phenytoin, lithium. Antagonized by phenobarbital, phenytoin, other hepatic enzyme inducers. May impair phenytoin clearance. Potentiated by cimetidine, other hepatic enzyme inhibitors. Interferes with serum chemistry tests.

See Also:

FLAGYL

Pharmacological Class:

Nitroimidazole.

Adverse Reactions:

Seizures, peripheral neuropathy, GI upset, anorexia, constipation, headache, metallic taste, ECT changes, dysuria.

How Supplied:

Tabs—50, 100; Caps 375mg—50

Indications for FLAGYL 375:

Trichomoniasis.

Adult:

375mg twice daily for 1 wk. Treat consorts also.

Children:

Not recommended.

Contraindications:

Pregnancy (1st trimester for trichomoniasis).

Warnings/Precautions:

CNS disease. Discontinue if neurological symptoms occur. Severe hepatic disease: reduce dose. History of blood dyscrasias. Monitor leukocytes before and after therapy. Elderly: monitor serum levels. Pregnancy (Cat.B, 2nd and 3rd trimesters). Nursing mothers: not recommended.

Interactions:

Avoid alcohol during and for 3 days after use. Do not give within 2 weeks of disulfiram (possible psychotic reactions). May potentiate oral anticoagulants, phenytoin, lithium. Antagonized by phenobarbital, phenytoin, other hepatic enzyme inducers. May impair phenytoin clearance. Potentiated by cimetidine, other hepatic enzyme inhibitors. Interferes with serum chemistry tests.

See Also:

FLAGYL

FLAGYL ER

Pharmacological Class:

Antiprotozoal/antibacterial.

Adverse Reactions:

GI upset, headache, metallic taste, dysuria, cystitis, incontinence, Candida overgrowth, seizures, peripheral neuropathy, ECT changes; neutropenia, pancreatitis (rare).

How Supplied:

Tabs—50, 100; ER—30; Caps 375mg—50

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