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Prostate and other male cancers
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Drug Name:


Generic Name and Formulations:
Degarelix 80mg/vial, 120mg/vial; pwd for SC inj after reconstitution.

Ferring Pharmaceuticals, Inc.

Therapeutic Use:

Indications for FIRMAGON:

Advanced prostate cancer.


Give by SC inj in abdomen once every 28 days; avoid waist and rib areas. Two 120mg injections once, then one 80mg inj once every 28 days.


Not established.


Pregnancy (Cat.X).


Congenital long QT syndrome. CHF. Correct electrolyte abnormalities. Monitor electrolytes and ECG periodically. Monitor serum PSA. Discontinue if serious hypersensitivity reaction occurs; do not rechallenge. Moderate or severe renal impairment (CrCl <50mL/min). Severe hepatic impairment. Nursing mothers: not recommended.


Caution with concomitant drugs known to prolong the QT interval.

Pharmacological Class:

GnRH antagonist.

Adverse Reactions:

Inj site reactions (eg, pain, erythema, swelling, induration), hot flashes, increased weight, fatigue, increased transaminases, increased gamma-glutamyltransferase; QT prolongation.

How Supplied:

Treatment Initiation pack (120mg/vial)—2 (w. supplies); Treatment Maintenance pack (80mg/vial)—1 (w. supplies)

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