This site is intended for healthcare professionals

ADD THIS DRUG TO MY LIST

Select the drug indication to add to your list

FACTIVE
Bacterial infections
Compare To Related Drugs
View/Edit/Compare Drugs In My List

Only 4 drugs may be compared at once

Drug Name:

FACTIVE Rx

Generic Name and Formulations:
Gemifloxacin mesylate 320mg; scored tabs.

Company:
Merus Labs International, Inc.

Therapeutic Use:

Indications for FACTIVE:

Susceptible infections including acute bacterial exacerbation of chronic bronchitis (ABECB) and mild-to-moderate community-acquired pneumonia. For ABECB: reserve for those who have no alternative treatment options.

Adult:

≥18yrs: Swallow whole. Take with full glass of water. 320mg once daily. ABECB: treat for 5 days. Community-acquired pneumonia: treat for 5 or 7 days (based on susceptible bacteria; see full labeling). Renal impairment and dialysis: CrCl ≤40mL/min: 160mg every 24hrs.

Children:

<18yrs: not established.

Warnings/Precautions:

Increased risk of disabling and potentially irreversible adverse reactions (including tendinitis/tendon rupture [esp. in patients >60yrs, or those with kidney, heart or lung transplants], peripheral neuropathy, or CNS effects); discontinue immediately if signs/symptoms occur. Epilepsy or predisposition to convulsions. History of myasthenia gravis; avoid. History of QT prolongation, ventricular arrhythmias, proarrhythmic conditions (eg, bradycardia, acute myocardial ischemia), electrolyte disorders (eg, hypokalemia, or hypomagnesemia); avoid. Do not exceed recommended dose and length of therapy esp. in renal or hepatic impairment; may increase QT prolongation. Discontinue at 1st sign of a skin rash, jaundice, or any other hypersensitivity. Maintain adequate hydration. Avoid excessive sun or UV light. Elderly. Pregnancy (Cat.C), nursing mothers: not recommended.

Interactions:

Avoid drugs that prolong QTc interval (eg, Class IA or Class III antiarrhythmics, erythromycin, antipsychotics, tricyclics). Separate dosing of magnesium- or aluminum-containing antacids and didanosine, sucralfate, iron, zinc, other metal cations (do not take within 3hrs before or 2hrs after gemifloxacin). Potentiated by probenecid. Increased risk of tendinitis/tendon rupture with corticosteroids. Monitor warfarin.

Pharmacological Class:

Quinolone.

Adverse Reactions:

Diarrhea, rash, nausea, urticaria, headache, abdominal pain, vomiting, dizziness, elevated liver enzymes; photosensitivity (discontinue if occurs), tendinitis/tendon rupture, torsades de pointes, peripheral neuropathy, convulsions, C. difficile-associated diarrhea.

Generic Availability:

YES

How Supplied:

Tabs—5, 7

Join MIMS Learning now to manage all your CPD and notes in one place!

By registering you agree with our Terms and Conditions and Privacy Policy.


Already a MIMS Learning member?

Sign In Now »
Red flag CPD modules
0.50 Credits
Red flags

Groin swelling - red flag symptomsExternal web site

This red flags article explains signs and symptoms of potentially serious pathology in patients presenting...

0.50 Credits
Red flags

Erectile dysfunction - red flag symptomsExternal web site

This article by Dr Tillmann Jacobi covers the possible red flag symptoms to consider when a patient...

0.50 Credits
Red flags

Headache - red flag symptomsExternal web site

Dr Suneeta Kochhar provides an overview of red flag symptoms in patients presenting with headaches...

Font Awesome Icons
View more
Clinical review CPD modules
1.50 Credits
Clinical Review

Basal cell carcinoma: clinical reviewExternal web site

In this article, Dr David Brass and Dr Neil Rajan discuss the risk factors for BCC, making the diagnosis...

1.50 Credits
Clinical Review

Cardiomyopathy: clinical reviewExternal web site

This article by Dr Rajiv Sankaranarayanan covers the diagnosis and management of cardiomyopathy. Key...

1.50 Credits
Clinical Review

Parkinson's disease: clinical reviewExternal web site

Dr Benjamin Simpson provides an in-depth overview of Parkinson’s disease, including information on risk...

Font Awesome Icons
View more

is free, fast, and customized just for you!

Already a member?

Sign In Now »