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EVOMELA
Leukemias, lymphomas, and other hematologic cancers
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Drug Name:

EVOMELA Rx

Generic Name and Formulations:
Melphalan HCl 50mg/vial; lyophilized pwd; for IV infusion after reconstitution.

Company:
Spectrum Pharmaceuticals, Inc.

Therapeutic Use:

Indications for EVOMELA:

High-dose conditioning treatment prior to hematopoietic progenitor (stem) cell transplantation in patients with multiple myeloma. Palliative treatment of multiple myeloma when oral therapy is not appropriate.

Adult:

Give prophylactic antiemetics. Conditioning treatment: Give by IV infusion over 30 minutes. 100mg/m2 daily for 2 consecutive days (Days -3 and -2) prior to transplantation (Day 0). If patient weighs >130% of their ideal body weight, use adjusted ideal body weight. Palliative treatment: Give by IV infusion over 15–20 minutes. 16mg/m2 as a single infusion at 2-week intervals for 4 doses, then at 4-week intervals after recovery from toxicity. Renal impairment (BUN ≥30mg/dL): consider up to 50% dose reduction for palliative treatment.

Children:

Not established.

Warnings/Precautions:

Prior irradiation or chemotherapy. Severe bone marrow suppression. Monitor CBCs during treatment; provide supportive care for infections, anemia, thrombocytopenia until adequate recovery. GI toxicity; provide supportive care. Monitor LFTs. Renal impairment. Embryo-fetal toxicity; use effective contraception during and after treatment. Pregnancy, nursing mothers: not recommended.

Interactions:

Caution with cyclosporine, BCNU, nalidixic acid.

Pharmacological Class:

Alkylating agent.

Adverse Reactions:

Decreased neutrophil, WBC, lymphocyte, and platelet counts, diarrhea, nausea, fatigue, hypokalemia, anemia, vomiting; hypersensitivity reactions, hepatic disorders, secondary malignancies, infertility.

Generic Availability:

NO

How Supplied:

Single-dose vial (20mL)—1

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