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ESTRASORB
Menopause and HRT
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Drug Name:

ESTRASORB Rx

Generic Name and Formulations:
Estradiol hemihydrate 2.5mg/g; topical emulsion.

Company:
Medicis Pharmaceuticals Corp

Therapeutic Use:

Indications for ESTRASORB:

Moderate to severe vasomotor symptoms of menopause.

Adult:

Apply contents of 2 pouches (3.48g) onto legs (thigh and calf) daily each morning; use 1 pouch per leg. May taper or discontinue at 3–6 month intervals.

Children:

Not applicable.

Contraindications:

Undiagnosed abnormal genital bleeding. Known, suspected or history of breast cancer. Known or suspected estrogen-dependent neoplasia. Active DVT, PE or history of. Active arterial thromboembolic disease or history of. Hepatic impairment. Known protein C, protein S, or antithrombin deficiency or other known thrombophilic disorders. Pregnancy.

Warnings/Precautions:

Increased risk of cardiovascular disorders. Endometrial or breast cancer. Risk of probable dementia in women >65yrs of age. Gallbladder disease. Bone disease associated with hypercalcemia. Visual abnormalities. Consider the addition of a progestin in patients with an intact uterus to avoid endometrial hyperplasia. History of hypertriglyceridemia. Hepatic impairment. Monitor thyroid function. Conditions aggravated by fluid retention. Hypoparathyroidism. Endometriosis. Hereditary angioedema. Caution in asthma, diabetes, epilepsy, migraines, porphyria, SLE, hepatic hemangiomas. Do initial complete physical and repeat yearly (include Pap smear, mammogram, BP). Discontinue if jaundice, cardiac events, severe hypercalcemia, pancreatitis, sudden partial or complete vision loss, sudden onset of proptosis, diplopia, or migraine occurs. Discontinue at least 4–6 weeks before surgery type associated with increased risk of thromboembolism or during prolonged immobilization. Nursing mothers.

Interactions:

May be antagonized by CYP3A4 inducers (eg, phenobarbital, carbamazepine, rifampin, St. John’s wort). May be potentiated by CYP3A4 inhibitors (eg, erythromycin, clarithromycin, ketoconazole, itraconazole, ritonavir, and grapefruit juice). Avoid applying near sunscreen (increases estradiol absorption). May interefere with lab tests (eg, aPTT/PTT, thyroid, other binding proteins, cholesterol, glucose tolerance).

Pharmacological Class:

Estrogen.

Adverse Reactions:

See full labeling. Endometrial disorder, infection, breast pain, headache, sinusitis, pruritus, nausea, vomiting, breakthrough bleeding.

How Supplied:

Emulsion (1.74g/pouch)—56

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