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Eprosartan
Hypertension
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Drug Name:

Eprosartan Rx

Generic Name and Formulations:
Eprosartan (as mesylate) 400mg, 600mg; tabs.

Company:
Various generic manufacturers

Therapeutic Use:

Indications for Eprosartan:

Hypertension.

Adult:

Monotherapy: not volume depleted: initially 600mg once daily. Usual range: 400–800mg/day given as a single dose or in two divided doses. Moderate-to-severe renal impairment: max 600mg daily.

Children:

Not established.

Contraindications:

Concomitant aliskiren in patients with diabetes.

Warnings/Precautions:

Fetal toxicity may develop; discontinue if pregnancy is detected. Correct salt/volume depletion before beginning therapy or monitor closely. Monitor BP, renal function, electrolytes. Renal artery stenosis. Severe CHF. Neonates. Pregnancy (Cat.D); monitor. Nursing mothers: not recommended.

Interactions:

See Contraindications. Dual inhibition of the renin-angiotensin system with ARBs, ACEIs, or aliskiren may increase risk of hypotension, hyperkalemia, renal function changes; avoid. Avoid concomitant aliskiren in renal impairment (CrCl <60mL/min). May be antagonized by, and renal toxicity potentiated by NSAIDs, including COX-2 inhibitors; monitor renal function periodically in elderly and/or volume-depleted. May increase lithium levels; monitor.

Pharmacological Class:

Angiotensin II receptor blocker (ARB).

Adverse Reactions:

Viral infection, injury, fatigue, abdominal pain, hypertriglyceridemia, arthralgia, depression, urinary tract or upper respiratory tract infection, rhinitis, pharyngitis, coughing, hypotension, rhabdomyolysis (rare).

Note:

Formerly known under the brand name Teveten.

Metabolism:

Hepatic. 98% protein bound.

Elimination:

Biliary, renal.

How Supplied:

Contact supplier

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