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Drug Name:


Generic Name and Formulations:
Lamivudine 100mg; tabs.


Therapeutic Use:

Indications for EPIVIR-HBV:

Chronic hepatitis B associated with viral replication and active liver inflammation.


100mg once daily. Renal impairment: CrCl 30–49mL/min: 100mg for 1st dose then 50mg once daily; CrCl 15–29mL/min: 100mg for 1st dose then 25mg once daily; CrCl 5–14mL/min: 35mg for 1st dose then 15mg once daily; CrCl <5mL/min: 35mg for 1st dose then 10mg once daily.


<2yrs: not recommended. 2–17yrs: 3mg/kg (max 100mg) once daily. Renal impairment: consider dose reduction.


Concomitant zalcitabine.


Unrecognized or untreated HIV infection (do HIV testing and counseling before and periodically during treatment). Not for treatment of HIV and HBV co-infections (use doses appropriate for HIV). Suspend if lactic acidosis or hepatotoxicity (eg, hepatomegaly and steatosis) occurs. Risk factors for liver disease. Women, obesity, or prolonged nucleoside exposure: increased risk of toxicity. Post-treatment exacerbation of hepatitis B; monitor closely during and for several months after treatment. Emergence of resistance-associated HBV substitutions: monitor ALT and HBV DNA levels during treatment. Diabetes (oral soln). Reevaluate annually. Pregnancy. Nursing mothers.


See Contraindications. Caution with drugs eliminated by active organic cationic secretion (eg, trimethoprim). Increased lamivudine absorption with TMP/SMX; increased zidovudine levels with lamivudine (clinical significance unknown).

See Also:


Pharmacological Class:

Nucleoside analogue (reverse transcriptase inhibitor).

Adverse Reactions:

Ear, nose, and throat infections, sore throat, diarrhea; rare: lactic acidosis, severe hepatomegaly with steatosis, emergence of viral mutations.


Register pregnant patients exposed to lamivudine by calling (800) 258-4263.

Generic Availability:

Tabs (YES); Soln (NO)

How Supplied:

Tabs—60; Soln—240mL

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