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ENTEREG
Colorectal disorders
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Drug Name:

ENTEREG Rx

Generic Name and Formulations:
Alvimopan 12mg; hard-gelatin caps.

Company:
Merck & Co., Inc.

Therapeutic Use:

Indications for ENTEREG:

To accelerate the time to upper and lower gastrointestinal recovery following surgeries that include partial bowel resection surgery with primary anastomosis.

Adult:

Give 12mg 30mins to 5hrs before surgery, then 12mg twice daily starting on 1st post-op day until hospital discharge for up to 7 days; max 15 doses.

Children:

Not established.

Contraindications:

Opioid use, at therapeutic doses, for >7 consecutive days prior.

Warnings/Precautions:

For short-term hospital use only. Potential risk of MI with long-term use. Severe hepatic impairment, ESRD, complete GI obstruction, pancreatic or gastric anastomosis: not recommended. Mild-to-severe renal impairment or mild-to-moderate hepatic impairment: monitor closely; discontinue if adverse reactions occur. Recent (within week prior to surgery) use of >3 doses of opioids; monitor for GI events. Japanese patients (monitor). Pregnancy (Cat.B). Nursing mothers.

Pharmacological Class:

Opioid antagonist (peripheral).

Adverse Reactions:

Dyspepsia.

Note:

Available only to hospitals that enroll in Entereg Access Support and Education Program (EASE). For more information, and to enroll, call (877) 282-4786.

REMS:

YES

How Supplied:

Caps—30

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