This site is intended for healthcare professionals


Select the drug indication to add to your list

Thromboembolic disorders
Compare To Related Drugs
View/Edit/Compare Drugs In My List

Only 4 drugs may be compared at once

Drug Name:


Generic Name and Formulations:
Apixaban 2.5mg, 5mg; tabs.

Bristol-Myers Squibb and Pfizer

Therapeutic Use:

Indications for ELIQUIS:

To reduce risk of stroke and systemic embolism in patients with nonvalvular atrial fibrillation (AF). Prophylaxis of deep vein thrombosis (DVT), which may lead to pulmonary embolism (PE) in patients who have undergone hip or knee replacement surgery. Treatment of DVT or PE. To reduce risk of recurrent DVT and PE following initial therapy.


Nonvalvular AF: 5mg twice daily. If any two of the following: age ≥80yrs; body weight ≤60kg, serum creatinine ≥1.5mg/dL: 2.5mg twice daily. Prophylaxis of DVT: 2.5mg twice daily; give initial dose at 12–24hrs after surgery. Hip: treat for 35 days. Knee: treat for 12 days. Treatment of DVT, PE: 10mg twice daily for 7 days, then 5mg twice daily. Reduction in risk of recurrence of DVT, PE: 2.5mg twice daily after at least 6 months of DVT or PE treatment. Unable to swallow whole tabs: may crush tabs and suspend in water, D5W, apple juice, or mix with applesauce; alternatively, may crush tabs and suspend in 60mL of water or D5W, then immediately deliver through NG tube. Concomitant strong dual inhibitors of CYP3A4 and P-gp (eg, ketoconazole, itraconazole, ritonavir, clarithromycin): reduce dose by 50%; if already on 2.5mg twice daily, coadministration should be avoided. Switching from warfarin: discontinue warfarin, start Eliquis when INR is <2. Switching from Eliquis to warfarin: discontinue Eliquis and begin both parenteral anticoagulant and warfarin at the time the next dose of Eliquis would have been taken, discontinue parenteral anticoagulant when INR reaches acceptable range. Switching between Eliquis and anticoagulants other than warfarin: discontinue one being taken and begin the other at usual time of next dose. Discontinue at least 48hrs prior to surgery with moderate-to-high risk of bleeding or 24hrs for procedures with low risk of bleeding. Moderate hepatic impairment: dosing recommendation cannot be provided. Severe hepatic impairment: not recommended.


Not established.


Active pathological bleeding.


Premature discontinuation increases risk of thrombotic events; if discontinued for reason other than bleeding or therapy completion, consider alternative anticoagulant. Risk of spinal/epidural hematoma in anticoagulated patients receiving neuraxial anesthesia or undergoing spinal/epidural puncture (esp. post-op use of indwelling epidural/intrathecal catheters or concomitant drugs affecting hemostasis); monitor for signs/symptoms of neurological impairment. Increased risk of bleeding; evaluate any signs/symptoms of blood loss; discontinue if active pathological hemorrhage occurs. Not recommended as alternative to unfractionated heparin for initial treatment of PE in hemodynamically unstable patients or who require thrombolysis or pulmonary embolectomy. Patients with prosthetic heart valves: not recommended. Labor & delivery. Pregnancy (Cat.B). Nursing mothers: not recommended.


See Adult dose. Potentiated by dual inhibitors of CYP3A4 and P-gp. Antagonized by concomitant strong dual inducers of CYP3A4 and P-gp (eg, rifampin, carbamazepine, phenyt­oin, St. John’s wort); avoid. Increased risk of bleeding with concomitant aspirin, antiplatelet agents, fibrinolytics, other anticoagulants, heparin, thrombolytic agents, SSRIs, SNRIs, NSAIDs.

Pharmacological Class:

Factor Xa inhibitor.

Adverse Reactions:

Bleeding (may be serious or fatal), nausea, anemia.


Hepatic (CYP3A4; 1A2, 2C8, 2C9, 2C19, 2J2 [minor]); 87% protein bound.


Renal, fecal.

Generic Availability:


How Supplied:

Tabs—60, 180

Join MIMS Learning now to manage all your CPD and notes in one place!

By registering you agree with our Terms and Conditions and Privacy Policy.

Already a MIMS Learning member?

Sign In Now »
Red flag CPD modules
0.50 Credits
Red flags

Groin swelling - red flag symptomsExternal web site

This red flags article explains signs and symptoms of potentially serious pathology in patients presenting...

0.50 Credits
Red flags

Erectile dysfunction - red flag symptomsExternal web site

This article by Dr Tillmann Jacobi covers the possible red flag symptoms to consider when a patient...

0.50 Credits
Red flags

Headache - red flag symptomsExternal web site

Dr Suneeta Kochhar provides an overview of red flag symptoms in patients presenting with headaches...

Font Awesome Icons
View more
Clinical review CPD modules
1.50 Credits
Clinical Review

Basal cell carcinoma: clinical reviewExternal web site

In this article, Dr David Brass and Dr Neil Rajan discuss the risk factors for BCC, making the diagnosis...

1.50 Credits
Clinical Review

Cardiomyopathy: clinical reviewExternal web site

This article by Dr Rajiv Sankaranarayanan covers the diagnosis and management of cardiomyopathy. Key...

1.50 Credits
Clinical Review

Parkinson's disease: clinical reviewExternal web site

Dr Benjamin Simpson provides an in-depth overview of Parkinson’s disease, including information on risk...

Font Awesome Icons
View more

is free, fast, and customized just for you!

Already a member?

Sign In Now »