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DILAUDID INJECTION
Narcotic analgesics
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Drug Name:

DILAUDID INJECTION CII

Generic Name and Formulations:
Hydromorphone HCl 0.5mg/0.5mL, 1mg/mL, 2mg/mL, 4mg/mL; soln for IV, IM or SC inj; preservative-free; contains sulfites.

Company:
Fresenius Kabi USA

Therapeutic Use:

Indications for DILAUDID INJECTION:

Management of pain severe enough to require an opioid analgesic and for which alternative treatments are inadequate.

Limitations Of use:

Reserve for use in patients for whom alternative treatment options have not been tolerated or not provided adequate analgesia.

Adult:

Use lowest effective dose for shortest duration. Individualize. Initially 1–2mg SC or IM, or 0.2–1mg by slow IV (at least 2–3mins) every 2–3 hours as needed. Elderly, debilitated: initially 0.2mg IV. Renal or hepatic impairment: initially ¼ to ½ the usual dose. Conversion from other opioids: see full labeling. Withdraw gradually by 25–50% every 2–4 days.

Children:

Not established.

Contraindications:

Significant respiratory depression. Acute or severe bronchial asthma in an unmonitored setting or in the absence of resuscitative equipment. Known or suspected GI obstruction, including paralytic ileus. Dilaudid-HP: opioid non-tolerant.

Warnings/Precautions:

Life-threatening respiratory depression; monitor within first 24–72hrs of initiating therapy and following dose increases. COPD, cor pulmonale, decreased respiratory reserve, hypoxia, hypercapnia, or pre-existing respiratory depression; monitor and consider non-opioid analgesics. Abuse potential (monitor). Adrenal insufficiency. Head injury. Increased intracranial pressure, brain tumors; monitor. Seizure disorders. CNS depression. Impaired consciousness, coma, shock; avoid. Biliary tract disease. Acute pancreatitis. Drug abusers. Renal or hepatic impairment. Reevaluate periodically. Avoid abrupt cessation. Elderly. Cachectic. Debilitated. Pregnancy; potential neonatal opioid withdrawal syndrome during prolonged use. Labor & delivery: not recommended. Nursing mothers: monitor infants.

Interactions:

Increased risk of hypotension, respiratory depression, sedation with benzodiazepines or other CNS depressants (eg, non-benzodiazepine sedatives/hypnotics, anxiolytics, general anesthetics, phenothiazines, tranquilizers, muscle relaxants, antipsychotics, alcohol, other opioids); reserve concomitant use in those for whom alternative options are inadequate; limit dosages/durations to minimum required; monitor. During or within 14 days of MAOIs: not recommended. Risk of serotonin syndrome with serotonergic drugs (eg, SSRIs, SNRIs, TCAs, triptans, 5-HT3 antagonists, mirtazapine, trazodone, tramadol, MAOIs, linezolid, IV methylene blue); monitor and discontinue if suspected. Avoid concomitant mixed agonist/antagonist opioids (eg, butorphanol, nalbuphine, pentazocine) or partial agonist (eg, buprenorphine); may reduce effects and precipitate withdrawal symptoms. May antagonize diuretics; monitor. Paralytic ileus may occur with anticholinergics.

See Also:

DILAUDID-HP INJECTION

Pharmacological Class:

Opioid agonist.

Adverse Reactions:

Lightheadedness, dizziness, sedation, nausea, vomiting, sweating, flushing, dysphoria, euphoria, dry mouth, pruritus; respiratory depression, severe hypotension, syncope.

How Supplied:

Prefilled syringes—24

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