Generic Name and Formulations:
Dicloxacillin sodium 250mg, 500mg; caps.
Various generic manufacturers
Susceptible infections caused by penicillinase-producing staphylococci. Not for initial therapy in serious, life-threatening infections.
Take on an empty stomach. ≥40kg: Mild to moderate infections: 125mg every 6hrs. Severe infections: 250mg every 6hrs.
Take on an empty stomach. <40kg: Mild to moderate infections: 12.5mg/kg/day in divided doses every 6hrs. Severe: 25mg/kg/day in divided doses every 6hrs.
Signficant allergy/asthma. Monitor blood, renal, and hepatic function in long-term use. Labor & delivery. Pregnancy (Cat.B). Nursing mothers.
Avoid concomitant tetracyclines, aminoglycosides. Serum levels increased by probenecid. May reduce anticoagulant response: monitor PT.
GI upset, hypersensitivity reactions, neurotoxic reactions, blood dyscrasias; C. difficile associated diarrhea.
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