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Drug Name:


Generic Name and Formulations:
Metyrosine 250mg; caps.

Valeant Pharmaceuticals, Inc

Therapeutic Use:

Indications for DEMSER:

Treatment of pheochromocytoma for: preoperative preparation for surgery; or management when surgery is contraindicated. Chronic treatment in malignant pheochromocytoma.


Initially 250mg 4 times daily; may increase by 250–500mg daily up to max 4g/day in divided doses. Usual dose: 2–3g/day; monitor. If hypertensive, titrate dose to normalize BP and control symptoms; if normotensive, titrate dose to reduce urinary metanephrines and/or vanillylmandelic acid by ≥50%. Add an α-blocker (eg, phenoxybenzamine) if patients not adequately controlled. Pre-op prep: treat for at least 5–7 days.


Not recommended.


Renal or hepatic impairment. Maintain adequate hydration; if crystalluria occurs, increase more fluids; if crystalluria persists, reduce dose or discontinue. Pre-op use: maintain adequate intravascular volume intra- and postoperatively. Pregnancy (Cat.C). Nursing mothers.


Increased CNS effects with alcohol, other CNS depressants (eg, hypnotics, sedatives, tranquilizers). Potentiates extrapyramidal effects of phenothiazines, haloperidol.

Pharmacological Class:

Tyrosine hydroxylase inhibitor.

Adverse Reactions:

Sedation, diarrhea, extrapyramidal effects, anxiety, CNS disturbances, crystalluria; rare: hematological disorders.

How Supplied:


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