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Drug Name:


Generic Name and Formulations:
Dextranomer microspheres 50mg/mL viscous gel in stabilized hyaluronic acid 15mg/mL carrier gel; implant for submucosal inj.

Valeant Pharmaceuticals, Inc

Therapeutic Use:

Indications for DEFLUX:

Vesicoureteral reflux (VUR) grades II–IV in children.


Not applicable.


<1yr: not recommended. ≥1yr: see literature. Must use Deflux metal needle for administration. Inject submucosally in urinary bladder near the ureteral orifice.


Non-functional kidney. Hutch diverticulum. Ureterocele. Active voiding dysfunction. Ongoing UTI.


Do not inject intravascularly. Must be administered by qualified surgeon experienced in the use of cystoscope and trained in subureteric injection procedures. Use of >6mL (3mL at each ureteral orifice) at same treatment session: not recommended. Treatment of duplex systems has not been studied. Ureters with grossly dilated orifices. Infection and bleeding risks associated with cystoscopic procedure.

Adverse Reactions:

UTI, ureteral dilatation, nausea, vomiting, abdominal pain.

How Supplied:

Single-use syringe (1mL)—1

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