Generic Name and Formulations:
Misoprostol 100mcg, 200mcg; tabs.
Prevention of NSAID-induced gastric ulcers.
Take with food. 200mcg 4 times daily with meals (last dose at bedtime). May reduce dose if not tolerated.
Can cause birth defects, abortion, premature birth or uterine rupture in pregnant women. For women of childbearing potential: negative serum pregnancy test within 2 weeks before starting therapy; begin on 2nd or 3rd day of next menstrual period; maintain contraception during therapy; give oral and written warnings on risks in pregnancy. Cardiovascular disease. Inflammatory bowel disease. Dehydration. Labor & delivery. Nursing mothers.
Avoid magnesium-containing antacids (to reduce diarrhea risk). Concomitant oxytocic agents: not recommended.
Prostaglandin E1 analogue.
Diarrhea, abdominal pain, headache, gynecological effects (eg, spotting, cramps), abortion, premature birth, birth defects, uterine rupture.
Tabs 100mcg—60, 120; 200mcg—60, 100
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