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CORZIDE
Hypertension
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Drug Name:

CORZIDE Rx

Generic Name and Formulations:
Nadolol, bendroflumethiazide; 40mg/5mg, 80mg/5mg; scored tabs.

Company:
Pfizer Inc.

Therapeutic Use:

Indications for CORZIDE:

Hypertension.

Adult:

Titrate components. Renally impaired: increase dosing interval; see literature.

Children:

Not recommended.

Contraindications:

Asthma. Sinus bradycardia. 2nd- or 3rd-degree AV block. Overt heart failure. CHF. Cardiogenic shock. Anuria. Sulfonamide allergy.

Warnings/Precautions:

Ischemic heart disease. Bronchospastic disease, COPD. Renal or hepatic dysfunction. Gout. Diabetes. Postsympathectomy. Hyperthyroidism. Monitor electrolytes, renal function. Surgery. SLE. Avoid abrupt cessation. Pregnancy (Cat.C). Nursing mothers: not recommended.

Interactions:

Hypotension with alcohol, CNS depressants, MAOIs, prazosin, other antihypertensives. Bradycardia with catecholamine-depleting drugs. Adjust antidiabetic, anticoagulant medication. ACTH, amphotericin B, corticosteroids increase hypokalemia risk. May increase toxicity of diazoxide, digitalis, lithium, verapamil, lidocaine. Antagonized by NSAIDs. Antagonizes methenamine, antigout drugs. May block epinephrine. May interfere with glaucoma, parathyroid screening tests.

Pharmacological Class:

Noncardioselective beta-blocker + diuretic.

Adverse Reactions:

Cardiac failure, bronchospasm, bradycardia, heart block, fatigue, fluid and electrolyte imbalance, orthostatic hypotension, GI upset, dizziness, blurred vision, cold extremities, rash, pruritus, blood dyscrasias.

How Supplied:

Tabs—100

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