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COREG
CHF and arrhythmias
Hypertension
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Drug Name:

COREG Rx

Generic Name and Formulations:
Carvedilol 3.125mg, 6.25mg, 12.5mg, 25mg; tabs.

Company:
GlaxoSmithKline

Therapeutic Use:

Indications for COREG:

Mild to severe heart failure (HF), to increase survival and reduce hospitalization risk. To reduce cardiovascular mortality post-MI with left ventricular ejection fraction ≤40%.

Adult:

Take with food. Monitor dose increases closely. ≥18yrs: CHF: initially 3.125mg twice daily for 2 weeks, may double dose every 2 weeks if tolerated; mild to moderate HF (>85kg): usual max 50mg twice daily. Reduce dose if pulse <55. Post-MI: initially 6.25mg twice daily; increase to 12.5mg twice daily after 3–10 days if tolerated; then to target dose 25mg twice daily. Low BP or heart rate, or fluid retention: may start at 3.125mg twice daily.

Children:

<18yrs: not recommended.

Contraindications:

Cardiogenic shock or decompensated HF requiring intravenous inotropic therapy. Asthma, related bronchospastic conditions. 2nd or 3rd-degree AV block, sick sinus syndrome, or severe bradycardia, unless paced. Severe hepatic impairment.

Warnings/Precautions:

Peripheral vascular disease. Nonallergic bronchospasm. Diabetes (monitor blood glucose). Hyperthyroidism. Monitor renal function in ischemic heart disease, diffuse vascular disease, underlying renal insufficiency, and/or if systolic BP <100 mmHg. Initiation of therapy may temporarily worsen signs and symptoms; benefits may be delayed for several weeks; may need increased diuretic dose at first. Avoid abrupt cessation. Prinzmetal's angina. Pheochromocytoma. Elderly. Pregnancy. Nursing mothers.

Interactions:

May be potentiated by CYP2D6 inhibitors (eg, quinidine, fluoxetine, paroxetine, propafenone), alcohol (separate by 2 hours). Bradycardia, hypotension with catecholamine depletors (eg, reserpine, MAOIs). Carvedilol levels reduced by rifampin. Increased absorption with cimetidine. Caution with drugs that affect cardiac conduction (esp. diltiazem, verapamil). May potentiate antidiabetic agents. Monitor digoxin, cyclosporine when changing carvedilol dose. Anesthesia.

See Also:

COREG CR

Pharmacological Class:

Noncardioselective beta-blocker/alpha-1 blocker.

Adverse Reactions:

Dizziness, edema, hypotension, syncope, bradycardia, AV block, GI upset, hyperglycemia, weight gain, abnormal vision.

How Supplied:

CR caps—30, 90; Tabs—100

Indications for COREG:

Hypertension.

Adult:

Take with food. ≥18yrs: initially 6.25mg twice daily; may increase as tolerated at 1–2 week intervals to 12.5mg twice daily. Max 25mg twice daily.

Children:

<18yrs: not recommended.

Contraindications:

Cardiogenic shock or decompensated HF requiring intravenous inotropic therapy. Asthma, related bronchospastic conditions. 2nd or 3rd-degree AV block, sick sinus syndrome, or severe bradycardia, unless paced. Severe hepatic impairment.

Warnings/Precautions:

Peripheral vascular disease. Nonallergic bronchospasm. Diabetes (monitor blood glucose). Hyperthyroidism. Monitor renal function in ischemic heart disease, diffuse vascular disease, underlying renal insufficiency, and/or if systolic BP <100mmHg. Avoid abrupt cessation. Prinzmetal's angina. Pheochromocytoma. Elderly. Neonates. Pregnancy (monitor). Nursing mothers.

Interactions:

May be potentiated by CYP2D6 inhibitors (eg, quinidine, fluoxetine, paroxetine, propafenone), alcohol (separate by 2 hours). Bradycardia, hypotension with catecholamine depletors (eg, reserpine, MAOIs). Carvedilol levels reduced by rifampin. Increased absorption with cimetidine. Caution with drugs that affect cardiac conduction (esp. diltiazem, verapamil). May potentiate antidiabetic agents. Monitor digoxin, cyclosporine when changing carvedilol dose. Anesthesia.

See Also:

COREG CR

Pharmacological Class:

Noncardioselective beta-blocker/alpha-1 blocker.

Adverse Reactions:

Bradycardia, orthostatic hypotension, dizziness, nasopharyngitis, GI upset, edema.

How Supplied:

CR caps—30, 90; Tabs—100

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