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Drug Name:

Cladribine Rx

Generic Name and Formulations:
Cladribine 1mg/mL; soln for IV infusion after dilution; preservative-free.

Various generic manufacturers

Therapeutic Use:

Indications for Cladribine:

Active hairy cell leukemia.


Give by continuous IV infusion for 7 consecutive days. 0.09mg/kg per day.


See full labeling.


Delay or discontinue if neurotoxicity or renal toxicity occurs. Myelosuppression. Active infection. Renal or hepatic insufficiency. Monitor blood counts (esp. during first 4–8 weeks post-dose), renal and hepatic function. Pregnancy (Cat.D), nursing mothers: not recommended.


Live attenuated vaccines: not recommended. Increased toxicity with myelosuppressive, immunosuppressive, or nephrotoxic agents.

Pharmacological Class:

Chlorinated purine nucleoside analog.

Adverse Reactions:

Severe myelosuppression (eg, neutropenia, anemia, thrombocytopenia), fever, infection, fatigue, nausea, rash, headache, inj site reactions, others; neurotoxicity, nephrotoxicity, tumor lysis syndrome (rare).



Generic Availability:


How Supplied:

Contact supplier.

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