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Cisplatin
Bladder, kidney, and other urologic cancers
Gynecologic cancers
Prostate and other male cancers
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Drug Name:

Cisplatin Rx

Generic Name and Formulations:
Cisplatin 1mg/mL; soln for IV infusion after dilution.

Company:
Various generic manufacturers

Therapeutic Use:

Indications for Cisplatin:

As a single agent, for treating transitional cell bladder cancer.

Adult:

Give by IV infusion over 6–8 hours. 50–70mg/m2 IV per cycle once every 3–4 weeks; heavily pretreated patients: initially 50mg/m2 IV per cycle every 4 weeks. Usual max: 100mg/m2 per cycle. Subsequent cycles: give as tolerated, withhold dose if serum creatinine, BUN, platelets, WBCs, or auditory acuity out of normal limits; see literature.

Children:

Not recommended.

Contraindications:

Renal or hearing impairment. Myelosuppression. Pregnancy (Cat.D). Nursing mothers.

Warnings/Precautions:

Have epinephrine, antihistamine available. Monitor baseline and pre-treatment renal function, electrolytes, auditory function; do periodic CBCs (weekly), liver function tests, neurologic exam. Hydrate patient before dosing. Avoid extravasation. Elderly.

Interactions:

Potentiates nephrotoxicity with other nephrotoxic drugs (eg, aminoglycosides). May antagonize anticonvulsants. May be antagonized by pyridoxine.

Pharmacological Class:

Platinum coordination complex.

Adverse Reactions:

Nephrotoxicity, neurotoxicity (eg, peripheral neuropathies), ototoxicity, myelosuppression, hemolytic anemia, marked nausea and vomiting, vascular toxicity (eg, MI, TIA), electrolyte disturbances, hyperuricemia, SIADH, hepatotoxicity, anaphylactic-like reactions, others; see literature.

Note:

Avoid contact with aluminum (eg, needles). Formerly known under the brand name Platinol.

How Supplied:

Contact supplier.

Indications for Cisplatin:

As a single agent, for secondary therapy of metastatic ovarian tumor. Adjunctive therapy for ovarian tumor.

Adult:

Give by IV infusion over 6–8 hours. 100mg/m2 IV per cycle once every 4 weeks; or, (when given with cyclophosphamide): 75–100mg/m2 IV per cycle once every 4 weeks. Usual max: 100mg/m2 per cycle. Subsequent cycles: give as tolerated, withhold dose if serum creatinine, BUN, platelets, WBCs, or auditory acuity out of normal limits; see literature.

Children:

Not recommended.

Contraindications:

Renal or hearing impairment. Myelosuppression. Pregnancy (Cat.D). Nursing mothers.

Warnings/Precautions:

Have epinephrine, antihistamine available. Monitor baseline and pre-treatment renal function, electrolytes, auditory function; do periodic CBCs (weekly), liver function tests, neurologic exam. Hydrate patient before dosing. Avoid extravasation. Elderly.

Interactions:

Potentiates nephrotoxicity with other nephrotoxic drugs (eg, aminoglycosides). May antagonize anticonvulsants. May be antagonized by pyridoxine.

Pharmacological Class:

Platinum coordination complex.

Adverse Reactions:

Nephrotoxicity, neurotoxicity (eg, peripheral neuropathies), ototoxicity, myelosuppression, hemolytic anemia, marked nausea and vomiting, vascular toxicity (eg, MI, TIA), electrolyte disturbances, hyperuricemia, SIADH, hepatotoxicity, anaphylactic-like reactions, others; see literature.

Note:

Avoid contact with aluminum (eg, needles). Formerly known under the brand name Platinol.

How Supplied:

Contact supplier.

Indications for Cisplatin:

Adjunctive therapy for metastatic testicular tumor.

Adult:

Give by IV infusion over 6–8 hours. 20mg/m2 IV daily for 5 days per cycle. Usual max: 100mg/m2 per cycle. Subsequent cycles: give as tolerated, withhold dose if serum creatinine, BUN, platelets, WBCs, or auditory acuity out of normal limits; see literature.

Children:

Not recommended.

Contraindications:

Renal or hearing impairment. Myelosuppression. Pregnancy (Cat.D). Nursing mothers.

Warnings/Precautions:

Have epinephrine, antihistamine available. Monitor baseline and pre-treatment renal function, electrolytes, auditory function; do periodic CBCs (weekly), liver function tests, neurologic exam. Hydrate patient before dosing. Avoid extravasation. Elderly.

Interactions:

Potentiates nephrotoxicity with other nephrotoxic drugs (eg, aminoglycosides). May antagonize anticonvulsants. May be antagonized by pyridoxine.

Pharmacological Class:

Platinum coordination complex.

Adverse Reactions:

Nephrotoxicity, neurotoxicity (eg, peripheral neuropathies), ototoxicity, myelosuppression, hemolytic anemia, marked nausea and vomiting, vascular toxicity (eg, MI, TIA), electrolyte disturbances, hyperuricemia, SIADH, hepatotoxicity, anaphylactic-like reactions, others; see literature.

Note:

Avoid contact with aluminum (eg, needles). Formerly known under the brand name Platinol.

How Supplied:

Contact supplier.

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