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Hereditary angioedema
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Drug Name:


Generic Name and Formulations:
C1 inhibitor (human) 500 Units/vial; lyophilized pwd for IV infusion after reconstitution; preservative-free.

Shire US, Inc.

Therapeutic Use:

Indications for CINRYZE:

Routine prophylaxis against angioedema attacks in adolescent and adult patients with hereditary angioedema (HAE).


Give by IV infusion at a rate of 1mL/min (10mins). 1000 Units every 3–4 days.


Not recommended.


Contains human plasma; monitor for possible infection transmission. Have epinephrine available to treat hypersensitivity reactions. Monitor patients with known risk factors for thrombotic events. Labor & delivery. Pregnancy (Cat.C). Nursing mothers.

Pharmacological Class:

C1 inhibitor.

Adverse Reactions:

Upper respiratory tract infection, sinusitis, rash, headache; thrombotic events, hypersensitivity reactions (may be severe); discontinue if occurs.


To report infections that may have been transmitted by Cinryze, call CinryzeSolutions at (877) 945-1000.

Generic Availability:


How Supplied:

Single-use vial—1

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