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Chlorthalidone
Edema
Hypertension
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Drug Name:

Chlorthalidone Rx

Generic Name and Formulations:
Chlorthalidone 25mg, 50mg; tabs.

Company:
Various generic manufacturers

Therapeutic Use:

Indications for Chlorthalidone:

Edema.

Adult:

Initially 50–100mg daily or 100mg on alternate days. Some may require 150–200mg at these intervals or up to 200mg daily. Maintenance: doses often lower than initial doses; individualize.

Children:

Not established.

Contraindications:

Anuria. Sulfonamide allergy.

Warnings/Precautions:

Renal or hepatic impairment. Diabetes. Gout. Asthma. SLE. Postsympathectomy. Excessive fluid loss. Monitor electrolytes; discontinue if electrolyte disorders develop rapidly. Pregnancy (Cat.B). Nursing mothers: not recommended.

Interactions:

Digitalis, lithium toxicity. Adjust antidiabetic, antigout medications. ACTH, corticosteroids, amphotericin B increase hypokalemia risk. Orthostatic hypotension with alcohol, CNS depressants. May potentiate nondepolarizing muscle relaxants, other antihypertensives (eg, ganglionic or peripheral adrenergic blocking agents). May antagonize norepinephrine. May interfere with parathyroid tests.

Pharmacological Class:

Diuretic (monosulfamyl).

Adverse Reactions:

Electrolyte disorders (esp. hypokalemia), hyperglycemia, hyperuricemia, photosensitivity, orthostatic hypotension, GI disturbances, CNS reactions (eg, dizziness), hematologic reactions (eg, thrombocytopenia).

Note:

Formerly known under the brand name Hygroton.

How Supplied:

Contact supplier.

Indications for Chlorthalidone:

Hypertension.

Adult:

Initially 25mg once daily; if needed may increase to 50mg once daily. If additional control needed, increase to 100mg once daily or add second antihypertensive. Maintenance: doses should be lower than initial doses; individualize.

Children:

Not established.

Contraindications:

Anuria. Sulfonamide allergy.

Warnings/Precautions:

Renal or hepatic impairment. Diabetes. Gout. Asthma. SLE. Postsympathectomy. Excessive fluid loss. Monitor electrolytes; discontinue if electrolyte disorders develop rapidly. Pregnancy (Cat.B). Nursing mothers: not recommended.

Interactions:

Digitalis, lithium toxicity. Adjust antidiabetic, antigout medications. ACTH, corticosteroids, amphotericin B increase hypokalemia risk. Orthostatic hypotension with alcohol, CNS depressants. May potentiate nondepolarizing muscle relaxants, other antihypertensives (eg, ganglionic or peripheral adrenergic blocking agents). May antagonize norepinephrine. May interfere with parathyroid tests.

Pharmacological Class:

Diuretic (monosulfamyl).

Adverse Reactions:

Electrolyte disorders (esp. hypokalemia), hyperglycemia, hyperuricemia, photosensitivity, orthostatic hypotension, GI disturbances, CNS reactions (eg, dizziness), hematologic reactions (eg, thrombocytopenia).

Note:

Formerly known under the brand name Hygroton.

How Supplied:

Contact supplier.

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