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Chlorpromazine
Nausea
Psychosis
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Drug Name:

Chlorpromazine Rx

Generic Name and Formulations:
Chlorpromazine HCl 10mg, 25mg, 50mg, 100mg, 200mg; tabs; contains parabens.

Company:
Various generic manufacturers

Therapeutic Use:

Indications for Chlorpromazine:

Nausea and vomiting.

Adult:

10–25mg every 4–6hrs as needed.

Children:

<6months: not recommended. ≥6months: 0.25mg/lb every 4–6hrs.

Contraindications:

Coma. CNS or bone marrow depression. Reye's syndrome.

Warnings/Precautions:

Discontinue 48 hrs before to 24 hrs after myelography. Cardiovascular, respiratory, renal, or liver disease. Epilepsy. Glaucoma. History of breast cancer. Exposure to extreme heat or organophosphates. Asthma (inj). Monitor blood, liver, and ocular function. Elderly. Pregnancy, nursing mothers: not recommended.

Interactions:

Potentiates phenytoin, alcohol, other CNS depressants, propranolol. Potentiated by propranolol. Antagonized by anticholinergics. Atropine. Decreased guanethidine, anticoagulant effects.

See Also:

Chlorpromazine injection

Pharmacological Class:

Phenothiazine.

Adverse Reactions:

Tardive dyskinesia, drowsiness, jaundice, blood dyscrasias, hypotension, retinopathy, may mask emetic signs of disease, lowered seizure threshold, rash, skin pigmentation, anticholinergic effects, insomnia, extrapyramidal reactions, neuroleptic malignant syndrome.

Note:

Formerly known under the brand name Thorazine.

How Supplied:

Contact supplier.

Indications for Chlorpromazine:

Psychosis. Mania. Intractable hiccups. Severe childhood behavior problems. Tetany.

Adult:

Psychosis: initially 10mg 3–4 (or 25mg 2–3) times daily; may increase semiweekly by 25–50mg daily. Hiccups: 25–50mg 3–4 times daily. Severe psychosis: initially 25mg 3 times daily; may increase semiweekly by 20–50mg/day.

Children:

<6months: not recommended. ≥6months: initially 0.25mg/lb every 4–6hrs as needed.

Contraindications:

Coma. CNS or bone marrow depression. Reye's syndrome.

Warnings/Precautions:

Discontinue 48 hrs before to 24 hrs after myelography. Cardiovascular, respiratory, renal, or liver disease. Epilepsy. Glaucoma. History of breast cancer. Exposure to extreme heat or organophosphates. Asthma (inj). Monitor blood, liver, and ocular function. Elderly. Pregnancy, nursing mothers: not recommended.

Interactions:

Potentiates phenytoin, alcohol, other CNS depressants, propranolol. Potentiated by propranolol. Antagonized by anticholinergics. Atropine. Decreased guanethidine, anticoagulant effects.

See Also:

Chlorpromazine injection

Pharmacological Class:

Aliphatic phenothiazine.

Adverse Reactions:

Tardive dyskinesia, drowsiness, jaundice, blood dyscrasias, hypotension, retinopathy, may mask emetic signs of disease, lowered seizure threshold, rash, skin pigmentation, anticholinergic effects, insomnia, extrapyramidal reactions, neuroleptic malignant syndrome.

Note:

Formerly known under the brand name Thorazine.

How Supplied:

Contact supplier.

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