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CEFOTAN
Bacterial infections
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Drug Name:

CEFOTAN Rx

Generic Name and Formulations:
Cefotetan disodium 1g, 2g; IM or IV inj; sodium content 3.5mEq/g.

Company:
Teligent, Inc.

Therapeutic Use:

Indications for CEFOTAN:

Susceptible lower respiratory tract or urinary tract, skin and skin structure, bone and joint, gynecologic, intraabdominal infections. Surgical prophylaxis.

Adult:

IV: inject over 3–5mins. UTI: 500mg IV or IM every 12hrs or 1–2g IV or IM every 12–24hrs. Mild to moderate skin and skin structures: 2g IV every 24hrs or 1g IV or IM every 12hrs. Severe skin and skin structure: 2g IV every 12hrs. Other sites: 1–2g IV or IM every 12hrs. Severe: 2g IV every 12hrs. Life threatening: 3g IV every 12hrs; max 6g/day. Prophylaxis: 1–2g IV once 30–60 mins before surgery. CrCl <30mL/min: reduce dose or frequency, see full labeling. Hemodialysis: give ¼ of the usual dose every 24hrs on days between dialysis and ½ the usual dose on dialysis days.

Children:

Not established.

Contraindications:

Previous cephalosporin-associated hemolytic anemia.

Warnings/Precautions:

Penicillin or other allergy. Discontinue if allergic reaction occurs. Have epinephrine and other emergency measures available. Renal impairment. Renal or hepatobiliary dysfunction, poor nutritional state, cancer patients, or elderly: monitor prothrombin time. Monitor for hemolytic anemia or superinfection with prolonged use. GI disease (esp. colitis). Pregnancy (Cat.B). Nursing mothers.

Interactions:

Avoid alcohol for 72 hours after dosing. Increased nephrotoxicity with concomitant aminoglycoside; monitor renal function. May cause false (+) Clinitest, Benedict's or Fehling's soln. May interfere with creatinine tests.

Pharmacological Class:

Cephalosporin.

Adverse Reactions:

Diarrhea, nausea, rash, itching, local reactions, anaphylaxis, blood dyscrasias, elevated liver enzymes, fever; C. difficile-associated diarrhea.

Generic Availability:

YES

How Supplied:

Vials—10

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