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CAVERJECT
Erectile dysfunction
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Drug Name:

CAVERJECT Rx

Generic Name and Formulations:
Alprostadil 5mcg, 10mcg, 20mcg, 40mcg; per vial; lyophilized pwd for intracavernous inj after reconstitution; contains benzyl alcohol.

Company:
Pfizer Inc.

Therapeutic Use:

Indications for CAVERJECT:

Treatment of erectile dysfunction. Adjunct to other diagnostic tests in the diagnosis of erectile dysfunction.

Adult:

Inject into the dorso-lateral aspect of the proximal third of penis, avoid visible veins; rotate inj side and site. Determine optimum dose in office. If no response, may give 2nd dose after 1hr; if partial response occurs, wait 24hrs before next dose. Vasculogenic, psychogenic, or mixed etiology: initially 2.5mcg; if partial response, may give 2nd dose of 5mcg; may increase in increments of 5–10mcg until desired response. If no response to 1st dose, may give 2nd dose of 7.5mcg within 1hr; may increase in increments of 5–10mcg until desired response. Neurogenic etiology: initially 1.25mcg; may give 2nd dose of 2.5mcg, and 3rd dose of 5mcg; may increase in increments of 5mcg until desired response. Usual max: 60mcg and 3 inj/week; allow at least 24hrs between doses. Reduce dose if erection lasts over 1hr. Adjunct in diagnosis: see full labeling.

Children:

Not indicated; see Contraindications.

Contraindications:

Predisposition to priapism. Anatomical penile deformation. Penile implants. Patients for whom sexual activity is inadvisable or contraindicated. Women. Children. Newborns.

Warnings/Precautions:

Preexisting cardiovascular disease. Evaluate and treat underlying causes prior to initiating therapy. Treat priapism immediately. Patient must not adjust dose on own. Reevaluate every 3 months. Significant corpora cavernosa venous leakage. Monitor for signs of penile fibrosis. Discontinue if penile angulation, cavernosal fibrosis, or Peyronie's disease develops. Risk of needle breakage; use proper handling and injection techniques.

Interactions:

Concomitant vasoactive agents: not recommended. Caution with anticoagulants.

Pharmacological Class:

Prostaglandin.

Adverse Reactions:

Penile pain, prolonged erection, priapism, penile fibrosis, inj site hematoma or ecchymosis, prostatic disorder, penile rash or edema, other local effects, upper respiratory infection, hypertension, headache, increased risk of blood-borne diseases, others.

How Supplied:

Vials—6; Caverject Impulse 10mcg, 20mcg—2 (dual chamber syringe systems + supplies)

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