Generic Name and Formulations:
Doxazosin (as mesylate) 1mg, 2mg, 4mg, 8mg; scored tabs.
Initially 1mg once daily; may double dose every 1–2 weeks; max 8mg/day.
Severe hepatic impairment: not recommended. Monitor blood pressure and for orthostatic hypotension initially and if dose increased. Syncope. Cataract surgery (intraoperative floppy iris syndrome possible). Exclude prostate cancer.
Dizziness, fatigue, hypotension, edema, dyspnea; rare: priapism.
Initially 1 mg once daily. Titrate gradually (based on standing BP at 2–6 hours and 24 hours post-dose) at 2-week intervals if needed; max 16 mg/day.
Severe hepatic impairment: not recommended. Monitor for orthostatic hypotension initially and if dose increased. Cataract surgery (intraoperative floppy iris syndrome possible). Pregnancy (Cat.C). Nursing mothers.
Caution when adding other antihypertensives.
Syncope (esp. 1st dose and with increased doses), dizziness, somnolence, fatigue/malaise, edema, rhinitis, abnormal vision, tinnitus, epistaxis, orthostatic hypotension, sexual dysfunction, polyuria, urinary incontinence, ataxia, leukopenia, neutropenia, arrhythmia; rare: priapism.
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