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CARDIZEM CD
Angina
Hypertension
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Drug Name:

CARDIZEM CD Rx

Generic Name and Formulations:
Diltiazem HCl 120mg, 180mg, 240mg, 300mg, 360mg; ext-rel caps.

Company:
Valeant Pharmaceuticals, Inc

Therapeutic Use:

Indications for CARDIZEM CD:

Vasospastic and chronic stable angina.

Adult:

Initially 120–180mg once daily. Titrate over 7–14 days; usual max 480mg once daily. Concomitant simvastatin: max 240mg/day.

Children:

Not established.

Contraindications:

Sick sinus syndrome, 2nd- or 3rd-degree AV block unless paced. Hypotension. Acute MI and pulmonary congestion documented by X-ray on admission.

Warnings/Precautions:

CHF. Renal or hepatic impairment (monitor). Discontinue if persistent rash occurs. Elderly. Pregnancy (Cat.C). Nursing mothers: not recommended.

Interactions:

Concomitant ivabradine, rifampin, alcohol: avoid. Caution with digoxin, β-blockers, others that may affect cardiac conduction (may lead to AV block). Monitor heart rate with concomitant clonidine. Potentiates propranolol, benzodiazepines, buspirone, cyclosporine, carbamazepine, quinidine, lovastatin, simvastatin (limit to max 10mg/day); monitor. Caution with CYP3A4 substrates, inhibitors (eg, cimetidine), or inducers. Anesthetics may potentiate cardiac depression.

See Also:

CARDIZEM LA

CARDIZEM

Pharmacological Class:

Calcium channel blocker (CCB) (benzothiazepine).

Adverse Reactions:

Edema, headache, fatigue, dizziness, asthenia, 1st-degree AV block, bradycardia, rash (may be serious); rare: hypotension, liver abnormalities.

How Supplied:

LA tabs—30, 90; CD 120mg, 180mg, 240mg, 300mg—30, 90; CD 360mg—90; Tabs 30mg—100, 500; 60mg, 90mg, 120mg—100

Indications for CARDIZEM CD:

Hypertension.

Adult:

Initially 180–240mg once daily; adjust at 2-week intervals. Usual range: 240–360mg once daily; usual max 480mg once daily. Concomitant simvastatin: max 240mg/day.

Children:

Not established.

Contraindications:

Sick sinus syndrome, 2nd- or 3rd-degree AV block unless paced. Hypotension. Acute MI and pulmonary congestion documented by X-ray on admission.

Warnings/Precautions:

CHF. Renal or hepatic impairment (monitor). Discontinue if persistent rash occurs. Elderly. Pregnancy (Cat.C). Nursing mothers: not recommended.

Interactions:

Concomitant ivabradine, rifampin, alcohol: avoid. Caution with digoxin, β-blockers, others that may affect cardiac conduction (may lead to AV block). Monitor heart rate with concomitant clonidine. Potentiates propranolol, benzodiazepines, buspirone, cyclosporine, carbamazepine, quinidine, lovastatin, simvastatin (limit to max 10mg/day); monitor. Caution with CYP3A4 substrates, inhibitors (eg, cimetidine), or inducers. Anesthetics may potentiate cardiac depression.

See Also:

CARDIZEM LA

Pharmacological Class:

Calcium channel blocker (CCB) (benzothiazepine).

Adverse Reactions:

Edema, headache, fatigue, dizziness, asthenia, 1st-degree AV block, bradycardia, rash (may be serious); rare: hypotension, liver abnormalities.

How Supplied:

LA tabs—30, 90; CD 120mg, 180mg, 240mg, 300mg—30, 90; CD 360mg—90

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