Generic Name and Formulations:
Carbidopa, levodopa; 10mg/100mg, 25mg/100mg, 25mg/250mg; orally-disintegrating tabs; mint flavor; contains phenylalanine.
Various generic manufacturers
Discontinue levodopa at least 12 hrs before starting carbidopa/levodopa. Dissolve tabs on tongue. ≥18yrs: initially one 25/100 tab 3 times daily, or one 10/100 tab 3–4 times daily; increase every 1–2 days up to either 2 tabs of 25/100 or 2 tabs of 10/100 4 times daily. Patients taking levodopa >1500mg/day: initially one 25/250 tab 3–4 times daily; usual max carbidopa 200mg/day.
<18yrs: not recommended.
During or within 14 days of nonselective MAOIs. Narrow-angle glaucoma. Undiagnosed skin lesions. History of melanoma.
Severe cardiovascular or pulmonary disease. Asthma. Renal, hepatic, or endocrine disorders. History of peptic ulcer or MI with residual arrhythmias. Suicidal tendencies. Psychosis. Orthostatic hypotension. Chronic wide-angle glaucoma. Monitor renal, hepatic and cardiovascular function, intraocular pressure, blood counts. May stain body fluids. Pregnancy (Cat.C). Nursing mothers.
See Contraindications. Antagonized by phenothiazines, butyrophenones, risperidone, phenytoin, papaverine, isoniazid; possibly iron, high protein diets, excessive gastric acidity. Orthostatic hypotension with selegiline, antihypertensives. May be affected by metoclopramide. Hypertension, dyskinesia with tricyclics. May cause false (+) urinary ketone or Coombs test or false (–) urinary glucose (glucose oxidase) test.
Dopa-decarboxylase inhibitor + dopamine precursor.
Dyskinesias, GI upset, CNS disturbances (eg, hallucinations, confusion, depression, dizziness, headache, insomnia, somnolence), syncope, hypo- or hypertension, dyspnea, on-off phenomena, blepharospasm (may indicate excess dose), urine discoloration, lab abnormalities; rare: neuroleptic malignant syndrome.
Formerly known under the brand name Parcopa.
Join MIMS Learning now to manage all your CPD and notes in one place!
Already a MIMS Learning member?Sign In Now »
Fever in adults can have potentially serious causes, ranging from sepsis to malignancy. Dr Pipin Singh...
In this article Dr Pipin Singh advises on how to identify red flags in patients presenting with bone...
Dr Matthew West covers the red flags to look out for in pregnancy, including back pain, bleeding, headaches...
This article, updated in 2016 by Dr Anthony De Soyza, advises on causes, investigations and managing...
Dr Keith Barnard discusses the aetiology and symptoms of Brugada syndrome. Key learning points for GPs...
Dr Kirsty Le Doare and Dr Nuria Martinez-Alier describe the signs and symptoms of measles and outline...