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Colorectal disorders
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Drug Name:


Generic Name and Formulations:
Mesalamine 1g; supps.


Therapeutic Use:

Indications for CANASA:

Mild-to-moderately active ulcerative proctitis.


Retain supp in rectum for at least 1–3hrs. 1g once daily at bedtime. Treat for 3–6 weeks.


Not established.


Sulfasalazine or aspirin allergy. Renal or hepatic impairment. Evaluate renal function before starting and periodically during therapy. Monitor for acute intolerance syndrome; discontinue if suspected. May stain clothes. Elderly. Pregnancy. Nursing mothers.


Concomitant nephrotoxic agents (eg, NSAIDs) may increase risk of renal effects; monitor. Concomitant azathioprine or 6-mercaptopurine may increase risk of blood disorders; if unavoidable, monitor CBCs and platelets. May interfere with measurements by liquid chromatography of urinary normetanephrine; consider other alternative assay.

Pharmacological Class:


Adverse Reactions:

Dizziness, rectal pain, fever, rash, acne, colitis, headache, flatulence, abdominal pain, diarrhea, nausea; mesalamine-induced acute intolerance syndrome, hypersensitivity reactions (including myocarditis, pericarditis, pneumonitis, hematologic abnormalities), renal or hepatic failure.

How Supplied:

Supps—30, 42

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