Generic Name and Formulations:
Edetate calcium disodium (EDTA) 200mg/mL; IV, IM inj.
Medicis Pharmaceuticals Corp
Lead poisoning. Lead encephalopathy.
See full labeling. Maintain hydration. IM for children and overt lead encephalopathy. Blood lead levels 20–70micrograms/dL: 1g/m2 per day. IV: infuse over 8–12 hours. IM: divided doses every 8–12 hours. Treat for 5 days then stop for 2–4 days; may repeat. If levels over 70micrograms/dL: give with BAL; see full labeling.
Anuria. Renal disease. Hepatitis.
Increased intracranial pressure (IV). Monitor urinalysis, urinary sediment, electrolytes, renal and hepatic function. Discontinue at 1st sign of renal toxicity. Pregnancy (Cat.B). Nursing mothers.
Steroids may increase renal toxicity. May chelate zinc in insulin preparations.
Acute necrosis of proximal tubules (may result in fatal nephrosis), fever, chills, malaise, hypotension, arrhythmias, zinc deficiency, hypercalcemia, glycosuria, proteinuria, hematuria, large epithelial cells in urinary sediment, GI upset, polydipsia, histamine-like reactions, transient bone marrow depression, anemia, local reactions.
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