Generic Name and Formulations:
Buspirone HCl 5mg, 10mg, 15mg+, 30mg+; scored (+bi/trisected) tabs.
Various generic manufacturers
Take consistently with regard to food. Initially 7.5mg twice daily, may increase by 5mg/day every 2–3 days. Usual range: 20–30mg/day; max 60mg/day.
<6yrs: not recommended. 6–17yrs: doses of 7.5–30mg twice daily have been used.
Severe renal or hepatic impairment: not recommended. Elderly. Labor & delivery. Pregnancy (Cat.B). Nursing mothers: not recommended.
Hypertensive crisis with MAOIs: see Contraindications. Avoid alcohol, large amounts of grapefruit juice. Caution with other CNS drugs. May potentiate haloperidol, diazepam, nefazodone. Potentiated by nefazodone, verapamil, diltiazem, erythromycin, itraconazole, ketoconazole, ritonavir, other CYP3A4 inhibitors (use lower initial dose). Antagonized by rifampin, dexamethasone, phenytoin, phenobarbital, carbamazepine, other CYP3A4 inducers.
Dizziness, GI upset, headache, nervousness, CNS or emotional effects, nonspecific chest pain, tinnitus, dream disturbances.
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