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Buspirone
Anxiety/OCD
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Drug Name:

Buspirone Rx

Generic Name and Formulations:
Buspirone HCl 5mg, 10mg, 15mg+, 30mg+; scored (+bi/trisected) tabs.

Company:
Various generic manufacturers

Therapeutic Use:

Indications for Buspirone:

Anxiety.

Adult:

Take consistently with regard to food. Initially 7.5mg twice daily, may increase by 5mg/day every 2–3 days. Usual range: 20–30mg/day; max 60mg/day.

Children:

<6yrs: not recommended. 6–17yrs: doses of 7.5–30mg twice daily have been used.

Contraindications:

Concomitant MAOIs.

Warnings/Precautions:

Severe renal or hepatic impairment: not recommended. Elderly. Labor & delivery. Pregnancy (Cat.B). Nursing mothers: not recommended.

Interactions:

Hypertensive crisis with MAOIs: see Contraindications. Avoid alcohol, large amounts of grapefruit juice. Caution with other CNS drugs. May potentiate haloperidol, diazepam, nefazodone. Potentiated by nefazodone, verapamil, diltiazem, erythromycin, itraconazole, ketoconazole, ritonavir, other CYP3A4 inhibitors (use lower initial dose). Antagonized by rifampin, dexamethasone, phenytoin, phenobarbital, carbamazepine, other CYP3A4 inducers.

Pharmacological Class:

Azaspirone.

Adverse Reactions:

Dizziness, GI upset, headache, nervousness, CNS or emotional effects, nonspecific chest pain, tinnitus, dream disturbances.

How Supplied:

Contact supplier.

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