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Bupropion HCl Tablets
Mood disorders
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Drug Name:

Bupropion HCl Tablets Rx

Generic Name and Formulations:
Bupropion HCl 75mg, 100mg.

Various generic manufacturers

Therapeutic Use:

Indications for Bupropion HCl Tablets:

Major depressive disorder (MDD).


Swallow whole. Avoid bedtime dosing. ≥18yrs: initially 100mg twice daily for at least 3 days; if tolerated, increase to 100mg 3 times daily at least 6hrs apart; max increase 100mg/day per 3-day period. May increase after several weeks to max 450mg/day in 3 divided doses; max single dose: 150mg (give 400mg/day as 100mg 4 times daily at least 4hrs apart). Moderate-to-severe hepatic impairment: max 75mg once daily. Renal or mild hepatic impairment: consider reduced dose and/or dose frequency. Switching to Wellbutrin XL: give same total daily dose.


<18yrs: not established.


Seizure disorders. Bulimia. Anorexia nervosa. During or within 14 days of discontinuing MAOIs. Concomitant linezolid or IV methylene blue. Abrupt withdrawal of alcohol, benzodiazepines, barbiturates, or antiepileptics. Other forms of bupropion (eg, Zyban).


Not for treating bipolar depression or for smoking cessation. Increased risk of suicidal thinking and behavior in children, adolescents, and young adults; monitor all patients for clinical worsening or unusual behavioral changes. Monitor for neuropsychiatric adverse events (eg, behavioral changes, agitation, depression, suicidal ideation); evaluate and consider treatment continuation under closer monitoring, or discontinuation if occur. Pre-existing psychiatric disorders. Bipolar disorder. Mania/hypomania. Psychosis. Risk of seizures; discontinue if seizure occurs: do not restart. Angle-closure glaucoma. Unstable heart disease. CHF. Recent MI. Monitor BP before initiating and periodically during treatment. Hepatic or renal impairment (monitor closely). Reevaluate periodically. Maintain at lowest effective dose. Write ℞ for smallest practical amount. Elderly. Labor & delivery. Pregnancy (Cat.C). Nursing mothers.


See Contraindications. Do not start with concomitant linezolid or IV methylene blue; if treatment necessary, discontinue bupropion before starting. Monitor for 2 weeks or until 24hrs after last dose of linezolid or IV methylene blue, whichever comes first. Avoid alcohol. Levodopa, amantadine may increase CNS toxicity. Caution with drugs that lower seizure threshold (eg, theophylline, antidiabetics, anorectics, CNS stimulants, systemic steroids, tricyclic antidepressants, antipsychotics) or factors that lower seizure threshold (eg, opiate or cocaine addiction, excessive use of alcohol or sedatives). Caution with CYP2B6 inhibitors (eg, ticlopidine, clopidogrel) or drugs metabolized by CYP2D6 including antidepressants (eg, venlafaxine, nortriptyline, imipramine, desipramine, paroxetine, fluoxetine, sertraline), antipsychotics (eg, haloperidol, risperidone, thioridazine), β-blockers (eg, metoprolol), Class 1C antiarrhythmics (eg, propafenone, flecainide); consider dose reduction. Caution with CYP2B6 inducers (eg, ritonavir, lopinavir, efavirenz, carbamazepine, phenobarbital, phenytoin), tamoxifen; consider dose increase. May antagonize digoxin; monitor. May cause false (+) urine immunoassay test results for amphetamine.

See Also:



Pharmacological Class:


Adverse Reactions:

Dry mouth, nausea, insomnia, dizziness, pharyngitis, abdominal pain, agitation, anxiety, tremor, palpitation, sweating, tinnitus, myalgia, anorexia, urinary frequency, rash (rarely may be serious, eg, erythema multiforme, Stevens-Johnson syndrome), headache, blurred vision, tachycardia; hypertension.

Generic Availability:


How Supplied:

XL tabs 150mg—30, 90; 300mg—30; SR tabs—60; Tabs—contact supplier

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