This site is intended for healthcare professionals

ADD THIS DRUG TO MY LIST

Select the drug indication to add to your list

BRAVELLE
Infertility
Compare To Related Drugs
View/Edit/Compare Drugs In My List

Only 4 drugs may be compared at once

Drug Name:

BRAVELLE Rx

Generic Name and Formulations:
Urofollitropin (follicle-stimulating hormone) 75 IU; per vial; lyophilized pwd for SC or IM inj after reconstitution.

Company:
Ferring Pharmaceuticals, Inc.

Therapeutic Use:

Indications for BRAVELLE:

Induction of ovulation in patients with functional anovulatory infertility that is not due to ovarian failure, or stimulation of multiple follicles in ovulatory patients undergoing Assisted Reproductive Technologies (ART) who have previously received pituitary suppression.

Adult:

Individualize. Use lowest effective dose. Ovulation induction: Initially 150 IU SC or IM inj daily for 5 days in the 1st cycle; for subsequent cycles: base initial dose on ovarian response. ART: Initially 225 IU SC inj daily for 5 days starting on Day 2 or 3 of cycle; or may be given in combination with Menopur (total initial dose: max 225 IU [Bravelle 150 IU + Menopur 75 IU; or Bravelle 75 IU + Menopur 150 IU]). Ovulation induction or ART: adjust dose based on response in increments of 75-150 IU at intervals of at least 2 days; max 450 IU daily; usual max 12 days. Induce final maturation/ovulation of follicles with hCG (see Precautions).

Children:

Not applicable.

Contraindications:

Primary ovarian failure. Uncontrolled non-gonadal endocrinopathies (eg, thyroid, adrenal, pituitary). Undiagnosed abnormal uterine bleeding. Ovarian cysts or enlargement. Tumor of pituitary, hypothalamus, breast, ovary, or uterus. Pregnancy (Cat.X).

Warnings/Precautions:

Do complete gynecological and endocrinological exam first. Risk of ovarian hyperstimulation syndrome (OHSS); monitor for at least 2 weeks after hCG administration. Discontinue if severe OHSS occurs; consider hospitalization (see full labeling). Abnormal ovarian enlargement; monitor ovarian response and/or measure serum estradiol levels. Do not give hCG if abnormally enlarged ovaries on last day of Bravelle therapy to reduce OHSS development. Increased risk of thromboembolic events in severe obesity, thrombophilia, pregnancy, personal or family history of thrombosis. Nursing mothers: not recommended.

Adverse Reactions:

Headache, hot flashes, respiratory disorder, abdominal cramps/fullness/enlargement, nausea, pain, pelvic pain; ovarian enlargement or cysts, OHSS, thromboembolic events, ovarian torsion, multi-fetal gestation and birth, ectopic pregnancy, spontaneous abortion, ovarian neoplasms, risk of congenital malformations, hypersensitivity reactions.

How Supplied:

Single-dose vials—5 (w. diluent)

Join MIMS Learning now to manage all your CPD and notes in one place!

By registering you agree with our Terms and Conditions and Privacy Policy.


Already a MIMS Learning member?

Sign In Now »
Red flag CPD modules
0.50 Credits
Red flags

Groin swelling - red flag symptomsExternal web site

This red flags article explains signs and symptoms of potentially serious pathology in patients presenting...

0.50 Credits
Red flags

Erectile dysfunction - red flag symptomsExternal web site

This article by Dr Tillmann Jacobi covers the possible red flag symptoms to consider when a patient...

0.50 Credits
Red flags

Headache - red flag symptomsExternal web site

Dr Suneeta Kochhar provides an overview of red flag symptoms in patients presenting with headaches...

Font Awesome Icons
View more
Clinical review CPD modules
1.50 Credits
Clinical Review

Basal cell carcinoma: clinical reviewExternal web site

In this article, Dr David Brass and Dr Neil Rajan discuss the risk factors for BCC, making the diagnosis...

1.50 Credits
Clinical Review

Cardiomyopathy: clinical reviewExternal web site

This article by Dr Rajiv Sankaranarayanan covers the diagnosis and management of cardiomyopathy. Key...

1.50 Credits
Clinical Review

Parkinson's disease: clinical reviewExternal web site

Dr Benjamin Simpson provides an in-depth overview of Parkinson’s disease, including information on risk...

Font Awesome Icons
View more

is free, fast, and customized just for you!

Already a member?

Sign In Now »