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Drug Name:


Generic Name and Formulations:
Penicillin G benzathine 600,000 units/mL; susp for deep IM inj; contains parabens.

Pfizer Inc.

Therapeutic Use:

Indications for BICILLIN L-A:

Susceptible infections, including mild to moderate upper respiratory strep infections, syphilis. Follow-up prophylaxis of rheumatic heart disease, acute glomerulonephritis.


Give by deep IM inj into upper outer quadrant of buttock; rotate inj sites. Upper respiratory Group A strep: 1.2 million units once. Syphilis (primary, secondary, latent): 2.4 million units once; (tertiary and neurosyphilis): 2.4 million units every 7 days for 3 doses. Rheumatic heart disease, acute glomerulonephritis: 1.2 million units once per month, or 600,000 units every 2 weeks.


Give by deep IM inj into upper outer quadrant of buttock or midlateral thigh; rotate inj sites. Upper respiratory Group A strep (<60 lbs): 300,000 to 600,000 units once; (>60 lbs): 900,000 units once. Congenital syphilis (<2yrs): 50,000 units/kg once; (≥2yrs): individualize.


Avoid intraarterial, intravascular, or intraneural injection.


Not for IV use. Cephalosporin, imipenem, or other allergy: not recommended. Asthma. Monitor renal and hematopoietic function in prolonged use. Pregnancy (Cat.B). Nursing mothers.


Potentiated by probenecid. May cause false (+) glucose test with Clinitest.

Pharmacological Class:

Penicillinase-sensitive penicillin.

Adverse Reactions:

Rash, serum sickness, anaphylaxis, blood dyscrasias, neuropathy, nephropathy, inj site reactions.

How Supplied:

Tubex 600,000 or 1.2 million units/syr (1 mL, 2 mL)—10 (w. 1 or 1.25 inch needles); Disposable syringe 2.4million units/syr (4 mL)—10 (w. 2 inch needles)

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