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AVELOX I.V.
Bacterial infections
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Drug Name:

AVELOX I.V. Rx

Generic Name and Formulations:
Moxifloxacin (as HCl) 400mg/250mL; soln for IV infusion; latex- and preservative-free.

Company:
Bayer Healthcare Pharmaceuticals Inc.

Therapeutic Use:

Indications for AVELOX I.V.:

Susceptible infections including acute bacterial sinusitis (ABS), acute bacterial exacerbations of chronic bronchitis (ABECB), community acquired pneumonia, skin and skin structure, complicated intra-abdominal infections, plague. For ABS and ABECB: reserve for those who have no alternative treatment options.

Adult:

≥18yrs: 400mg once daily. ABS: treat for 10 days. ABECB: treat for 5 days. Pneumonia: treat for 7–14 days. Skin and skin structure: treat for 7 days, if complicated: 7–21 days. Intra-abdominal: treat for 5–14 days. Plague: treat for 10–14 days; begin as soon as possible after suspected or confirmed exposure. IV formulation may be used if oral route not preferable; administer IV infusion over 60 mins, may switch from IV to oral route when clinically indicated.

Children:

<18yrs: not established.

Warnings/Precautions:

Increased risk of disabling and potentially irreversible adverse reactions (including tendinitis/tendon rupture [esp. in patients >60yrs, or those with kidney, heart or lung transplants], peripheral neuropathy, or CNS effects); discontinue immediately if signs/symptoms occur. CNS disorders (eg, cerebral arteriosclerosis, epilepsy) that increase seizure risk. History of myasthenia gravis; avoid. History of QT prolongation, ventricular arrhythmias, proarrhythmic conditions (eg, bradycardia, acute myocardial ischemia), hypokalemia, or hypomagnesemia; avoid. Do not exceed recommended dose or infusion rate; may increase QT prolongation. Hepatic impairment. Monitor ECG in liver cirrhosis. Discontinue at 1st sign of a skin rash, jaundice, or any other hypersensitivity. Monitor blood glucose in diabetic patients; discontinue if hypoglycemia occurs. Maintain adequate hydration. Avoid excessive sun or UV light. Elderly. Pregnancy: avoid. Nursing mothers: not recommended.

Interactions:

Avoid drugs that prolong QTc interval (eg, Class IA or Class III antiarrhythmics, cisapride, erythromycin, antipsychotics, tricyclics). Oral forms: take at least 4hrs before or 8hrs after iron, zinc, magnesium, aluminum, sucralfate, didanosine (buffered forms). Increased risk of tendinitis/tendon rupture with corticosteroids. Monitor warfarin. Concomitant antidiabetics may cause blood glucose disturbances. Concomitant NSAIDs may increase seizure risk.

See Also:

AVELOX

Pharmacological Class:

Quinolone.

Adverse Reactions:

Nausea, diarrhea, dizziness, headache, convulsions, other CNS effects, abdominal pain, inj site reaction; hypersensitivity reactions, abnormal liver function tests, rash, phototoxicity (discontinue if occurs), tendinitis/tendon rupture, peripheral neuropathy, C. difficile-associated diarrhea.

Generic Availability:

YES

How Supplied:

Tabs—30; ABC Pack (5 tabs)—1; Premixed IV soln (250mL)—1

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