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ASMANEX TWISTHALER
Asthma/COPD
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Drug Name:

ASMANEX TWISTHALER Rx

Generic Name and Formulations:
Mometasone furoate 110mcg/inh, 220mcg/inh; pwd for oral inhalation; with dose counter.

Company:
Merck & Co., Inc.

Therapeutic Use:

Indications for ASMANEX TWISTHALER:

Maintenance treatment of asthma as prophylactic therapy.

Limitations Of use:

Not for relief of acute bronchospasm.

Adult:

Previously on bronchodilators alone or inhaled corticosteroids: initially 220mcg once in the PM; max 440mcg daily (either as 220mcg twice daily or 440mcg once daily). Previously on oral corticosteroids (wean gradually): initially 440mcg twice daily; max 880mcg daily. Rinse mouth after use.

Children:

<4yrs: not established. 4–11yrs: 110mcg once in the PM; max 110mcg daily. Rinse mouth after use.

Contraindications:

Primary treatment of status asthmaticus or acute asthma attacks. Milk protein allergy.

Warnings/Precautions:

Maintain regular regimen. Re-evaluate immediately during rapidly deteriorating asthma; may need oral corticosteroid therapy. Immunosuppressed. Untreated infections (eg, fungal, bacterial, viral, parasitic), TB, ocular herpes simplex. If exposed to chickenpox or measles, consider anti-infective prophylactic therapy. Transferring from systemic steroids: taper gradually. If adrenal insufficiency exists following systemic corticosteroids, replacement with inhaled steroids may exacerbate symptoms of adrenal insufficiency (eg, lassitude). Monitor for increased intraocular pressure, glaucoma, and/or cataracts; bone mineral density if other osteoporosis risk factors exist; and for growth suppression in children; hypercorticism and HPA axis suppression (if occurs, discontinue gradually). Severe hepatic impairment. Pregnancy (Cat.C). Nursing mothers.

Interactions:

Potentiated by strong CYP3A4 inhibitors (eg, ketoconazole).

Pharmacological Class:

Steroid.

Adverse Reactions:

Headache, allergic rhinitis, pharyngitis, upper respiratory tract infection, sinusitis, oral candidiasis, dysmenorrhea, musculoskeletal pain, back pain, dyspepsia; hypersensitivity reactions, paradoxical bronchospasm; discontinue if occurs. Children: also fever, bruise.

How Supplied:

Twisthaler 110mcg (30 inh)—1; 220mcg (30 inh, 60 inh, 120 inh)—1

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